Synthetic Amphoteric Cryogels as an Antidote against Acute Heavy Metal Poisoning

• Published in: Molecules (Basel, Switzerland) Switzerland), 2021-12, Vol.26 (24), p.7601
• Main Authors: Baimenov, Alzhan Z, Fakhradiyev, Ildar R, Berillo, Dmitriy A, Saliev, Timur, Mikhalovsky, Sergey V, Nurgozhin, Talgat S, Inglezakis, Vassilis J
• Format: Article
• Language: English
• Subjects: 2,3-Dimercapto-1-propanesulfonic acid; Adsorbents; Amphoterics; Animals; antidote; Antidotes; Antidotes - chemical synthesis; Antidotes - chemistry; Antidotes - pharmacology; Aqueous solutions; Biochemical analysis; Cadmium; Chelating agents; Chelating Agents - chemical synthesis; Chelating Agents - chemistry; Chelating Agents - pharmacology; Chelation; Chelation therapy; Chemical analysis; Confocal microscopy; cryogel; Cryogels - chemical synthesis; Cryogels - chemistry; Cryogels - pharmacology; DMPS; elimination; Enzymes; Food contamination & poisoning; Heavy Metal Poisoning - drug therapy; Heavy Metal Poisoning - metabolism; Heavy metals; Ligands; Liver; Male; Mercuric chloride; Metals, Heavy - metabolism; Microscopy; Nuclear power plants; Poisoning; Polymers; Radioisotopes; Rats; Scanning electron microscopy; Sodium salts; Sorbents; Sulfonic acid; Survival; Tissue analysis; Toxicity; X ray analysis
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules26247601

The effectiveness of an amphoteric cryogel (AAC) as an oral sorbent (enerosorbent) for the treatment of acute poisoning of small animals (rats) with heavy metals (HMs) was studied in in vivo experiments. The morphological structure of the cryogel was examined using scanning electron microscopy/energy-dispersive X-ray analysis and confocal microscopy. The use of the cryogel in the treatment of rats administered an LD dose of Cd(NO ) , CsNO , Sr(NO ) , or HgCl in aqueous solution showed their high survival rate compared to the control group, which did not receive such treatment. The histological and chemical analysis of internal tissues and the biochemical analysis of the blood of the experimental animals showed the effectiveness of the cryogel in protecting the animals against the damaging effect of HMs on the organism comparable with unithiol, a chelating agent based on 2,3-dimercapto-1-propane sulfonic acid sodium salt (DMPS) approved for the treatment of acute poisoning with some heavy metals.