Molecular pathologic interpretation of new retinoblastoma rosettes

Newly described retinoblastoma (RB) rosettes have various kinds of pathological significance. Some of their characteristics have been revealed in this immunohistochemistry study. Five paraffin-embedded eyeballs with RB and new rosettes were studied for neuron-specific enolase (NSE), p53, p16, BAX, c...

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Bibliographic Details
Published in:Indian journal of ophthalmology 2017-08, Vol.65 (8), p.764-767
Main Authors: Das, Dipankar, Deka, Panna, Bhattacharjee, Kasturi, Barman, Manab Jyoti, Bhattacharjee, Harsha, Misra, Divakant, Saxena, Rushil Kumar, Bhattacharyya, Anusuya, Deka, Apurba
Format: Article
Language:English
Subjects:
Bax protein
Biomarkers, Tumor - metabolism
Brief Communication
c-Myc protein
Cancer
Cell growth
Child
Differentiation
Genetic aspects
Glial fibrillary acidic protein
Humans
Immunohistochemistry
Medical prognosis
Molecular pathology
Myc protein
Neuronal-glial interactions
Ophthalmology
p53 Protein
Paraffin
Pathology
Phosphopyruvate hydratase
Prognosis
Retina
Retinal Neoplasms - diagnosis
Retinal Neoplasms - metabolism
Retinoblastoma
Retinoblastoma - diagnosis
Retinoblastoma - metabolism
Risk factors
rosette
Signal transduction
Studies
Synaptophysin
Technology transfer
Tumors
Citations: Items that this one cites
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Summary:Newly described retinoblastoma (RB) rosettes have various kinds of pathological significance. Some of their characteristics have been revealed in this immunohistochemistry study. Five paraffin-embedded eyeballs with RB and new rosettes were studied for neuron-specific enolase (NSE), p53, p16, BAX, c-Myc, glial fibrillary acidic protein, synaptophysin, and chromogranin. They were compared and interpreted using control specimens. NSE, P53, and P16 were significantly expressed in the cells of the new rosettes. The presence of new RB rosettes that mostly have histopathological high-risk factors and p53 positivity may be a strong marker of poor prognosis of RB.
ISSN:0301-4738
1998-3689
DOI:10.4103/ijo.IJO_316_16