17-Alpha-Hydroxyprogesterone vs. Placebo for Preventing of Recurrent Preterm Birth: A Systematic Review and Meta-Analysis of Randomized Trials

Preterm birth (PTB) is a leading cause of neonatal morbidity and mortality. To estimate the effect of 17-alpha-hydroxyprogesterone caproate (17-OHPC) compared to placebo in singleton gestations for reducing the risk of recurrent PTB and neonatal morbidity and mortality. Systematic review and meta-an...

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Bibliographic Details
Published in:Frontiers in medicine 2021-12, Vol.8, p.764855-764855
Main Authors: Almutairi, Abdulaali R, Aljohani, Hadir I, Al-Fadel, Nouf S
Format: Article
Language:English
Subjects:
17-alpha-hydroxyprogesterone caproate
17-OHPC
Medicine
preterm birth
recurrent preterm birth
systematic review and meta-analysis
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Summary:Preterm birth (PTB) is a leading cause of neonatal morbidity and mortality. To estimate the effect of 17-alpha-hydroxyprogesterone caproate (17-OHPC) compared to placebo in singleton gestations for reducing the risk of recurrent PTB and neonatal morbidity and mortality. Systematic review and meta-analysis. Searching MEDLINE, Embase, Web of Science, SCOPUS, Cochrane Library, and clinical trial registries. Randomized controlled trials of singleton gestations with a history of PTB and treated with a weekly intramuscular injection of 17-OHPC or placebo. A random meta-analysis model was performed for the PTB outcomes (
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2021.764855