Role of anterior segment optical coherence tomography angiography in the assessment of acute chemical ocular injury: a pilot animal model study

To examine the use of anterior segment-optical coherence tomography angiography (AS-OCTA) in the assessment of limbal ischemia in an animal model chemical ocular injury. We conducted a prospective study using an established chemical ocular injury model in 6 rabbits (12 eyes), dividing the cornea lim...

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Bibliographic Details
Published in:Scientific reports 2021-08, Vol.11 (1), p.16625-16625, Article 16625
Main Authors: Tey, Kai Yuan, Gan, Jinyuan, Foo, Valencia, Tan, Bingyao, Ke, Meng Yuan, Schmetterer, Leopold, Mehta, Jodhbir S., Ang, Marcus
Format: Article
Language:English
Subjects:
692/308/53/2422
692/700/1421
Angiography
Animal models
Cornea
Humanities and Social Sciences
Ischemia
Medical imaging
multidisciplinary
Science
Science (multidisciplinary)
Tomography
Vascularization
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Summary:To examine the use of anterior segment-optical coherence tomography angiography (AS-OCTA) in the assessment of limbal ischemia in an animal model chemical ocular injury. We conducted a prospective study using an established chemical ocular injury model in 6 rabbits (12 eyes), dividing the cornea limbus into 4 quadrants. Chemical injury grade was induced based on extent of limbal injury (0 to 360 degrees) and all eyes underwent serial slit-lamp with AS-OCTA imaging up to one month. Main outcome measure was changes in AS-OCTA vessel density (VD) comparing injured and control cornea limbal quadrants within 24 h and at one month. AS-OCTA was able to detect differences in limbal VD reduction comparing injured (3.3 ± 2.4%) and control quadrants (7.6 ± 2.3%; p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-96086-0