SRC-3, a Steroid Receptor Coactivator: Implication in Cancer

Steroid receptor coactivator-3 (SRC-3), also known as amplified in breast cancer 1 (AIB1), is a member of the SRC family. SRC-3 regulates not only the transcriptional activity of nuclear receptors but also many other transcription factors. Besides the essential role of SRC-3 in physiological functio...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-04, Vol.22 (9), p.4760
Main Authors: Li, Licen, Deng, Chu-Xia, Chen, Qiang
Format: Article
Language:English
Subjects:
AIB1
Breast cancer
cancer
Carcinogenesis
Carcinogens
Cell growth
Chromosomes
coactivator
Epidermal growth factor
Gene amplification
Gene expression
Hormones
Kinases
Localization
Medical prognosis
Metabolism
Metabolites
Nuclear receptors
Phosphorylation
Physiological effects
Proteins
Review
Roles
SRC-3
Steroids
Thyroid gland
Transcription factors
Tumorigenesis
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Summary:Steroid receptor coactivator-3 (SRC-3), also known as amplified in breast cancer 1 (AIB1), is a member of the SRC family. SRC-3 regulates not only the transcriptional activity of nuclear receptors but also many other transcription factors. Besides the essential role of SRC-3 in physiological functions, it also acts as an oncogene to promote multiple aspects of cancer. This review updates the important progress of SRC-3 in carcinogenesis and summarizes its mode of action, which provides clues for cancer therapy.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22094760