Immunoregulation role of the erythroid cells

Erythroid cells are the most abundant cells in the human body. In addition to their established function in gas-transportation, erythroid cells at various stages of differentiation have recently been shown to have immunomodulatory roles. Red blood cells may serve as modulators of innate and adaptive...

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Bibliographic Details
Published in:Frontiers in immunology 2024-10, Vol.15, p.1466669
Main Authors: Niu, Chunxiao, Zhang, Jiyan
Format: Article
Language:English
Subjects:
Animals
CD71 + erythroid cells
Erythroid Cells - immunology
Erythroid Cells - metabolism
erythropoiesis
Humans
Immunology
Immunomodulation
immunoregulation
Neoplasms - immunology
PD-L1
Pregnancy
ROS
TGF-β
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Summary:Erythroid cells are the most abundant cells in the human body. In addition to their established function in gas-transportation, erythroid cells at various stages of differentiation have recently been shown to have immunomodulatory roles. Red blood cells may serve as modulators of innate and adaptive immunity, while their immature counterparts, CD71 erythroid cells (CECs) have important immunomodulatory functions in various contexts. CECs are abundant in human cord blood and placenta, where they contribute to fetomaternal tolerance. CECs also accumulate in patients with infections, tumors, and anemia, and effectively suppress T cells by producing high levels of arginase, reactive oxygen species, programmed death-ligand 1, transforming growth factor β, and/or interleukin-10. Here, we systematically summarize the immunomodulatory functions of erythroid cells and propose some potential therapeutic applications based on their characteristics.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2024.1466669