Local and systemic inflammation after implantation of a novel iron based porous degradable bone replacement material in sheep model

Despite the high potential of healthy bone to regenerate, the reconstruction of large bone defects remains a challenge. Due to the lack of mechanical stability of existing bone substitutes, recently developed degradable metallic alloys are an interesting alternative providing higher load-bearing cap...

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Bibliographic Details
Published in:Scientific reports 2021-06, Vol.11 (1), p.12035-12035, Article 12035
Main Authors: Wegener, Bernd, Behnke, Maik, Milz, Stefan, Jansson, Volkmar, Redlich, Christian, Hermanns, Walter, Birkenmaier, Christof, Pieper, Korbinian, Weißgärber, Thomas, Quadbeck, Peter
Format: Article
Language:English
Subjects:
631/61/2035
639/301/54
Alloys
Animal research
Biocompatibility
Blood
Blood levels
Bone biomaterials
Bone implants
Ferritin
Humanities and Social Sciences
Inflammation
Iron
Lymph nodes
multidisciplinary
Phosphorus
Science
Science (multidisciplinary)
Tibia
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Summary:Despite the high potential of healthy bone to regenerate, the reconstruction of large bone defects remains a challenge. Due to the lack of mechanical stability of existing bone substitutes, recently developed degradable metallic alloys are an interesting alternative providing higher load-bearing capabilities. Degradable iron-based alloys therefore might be an attractive innovation. To test the suitability of a newly-designed iron-based alloy for such applications, an animal experiment was performed. Porous iron-based degradable implants with two different densities and a control group were tested. The implants were positioned in the proximal tibia of Merino sheep. Over a period of 6 and 12 months, blood and histological parameters were monitored for signs of inflammation and degradation. In the histological evaluation of the implants` environment we found degraded alloy particles, but no inflammatory reaction. Iron particles were also found within the popliteal lymph nodes on both sides. The serum blood levels of phosphorus, iron and ferritin in the long term groups were elevated. Other parameters did not show any changes. Iron-based degradable porous bone replacement implants showed a good biocompatibility in this experiment. For a clinical application, however, the rate of degradation would have to be significantly increased. Biocompatibility would then have to be re-evaluated.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-91296-y