Non-controlled, open-label clinical trial to assess the effectiveness of a dietetic food on pruritus and dermatologic scoring in atopic dogs

Canine atopic dermatitis (AD) is a common skin disease. The goal of this study was to evaluate food designed to improve skin barrier function and lower inflammation to reduce pruritus and clinical severity in client-owned atopic dogs. The food contained an antioxidant blend to reduce oxidative stres...

Full description

Saved in:
Bibliographic Details
Published in:BMC veterinary research 2019-06, Vol.15 (1), p.220-220, Article 220
Main Authors: Witzel-Rollins, Angela, Murphy, Maryanne, Becvarova, Iveta, Werre, Stephen R, Cadiergues, Marie-Christine, Meyer, Hein
Format: Article
Language:English
Subjects:
Advertising executives
Allergy
Antioxidants (Nutrients)
Atopic dermatitis
Atopy
Canine
Clinical trials
Dermatitis
Dermatology
Diet therapy
Dog diseases
Dogs
Fatty acids
Food and Nutrition
Functional foods
Immunology
Inflammation
Itching
Life Sciences
Medical research
Nutrition
Oxidative stress
Pet food
Pets
Phenols (Class of compounds)
Polyphenols
Skin
Skin diseases
Testing
Unsaturated fatty acids
Veterinary
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Canine atopic dermatitis (AD) is a common skin disease. The goal of this study was to evaluate food designed to improve skin barrier function and lower inflammation to reduce pruritus and clinical severity in client-owned atopic dogs. The food contained an antioxidant blend to reduce oxidative stress, plant polyphenols to stabilize mast cells, and polyunsaturated fatty acids to improve skin health and reduce inflammation. Seventeen dogs were included in the analysis. Initially 48 adult atopic dogs were enrolled and exclusively fed a dermatologic food for 8 weeks in a non-controlled, open-label study. Thirty-one dogs were excluded for the following reasons: oral and topical medication changes (n = 17), missing data (n = 4), fatty acid supplementation (n = 3), food refusal (n = 3), dropped out (n = 3), and owner concerns (n = 1). Using a scale from 0 (normal) - 4 (severe), veterinarians evaluated the presence and severity of clinical signs of atopy at weeks 0, 4, and 8. Pet owners also rated their pet's clinical signs of atopy on a scale from 0 (not present) - 10 (present continuously) at weeks 0, 4, and 8. Compared with initial baseline scores (median 19, range 3-69), the total veterinarian scores were significantly lower at weeks 4 (median 11, range 1-15) and 8 (median 7, range 3-46) (p 
ISSN:1746-6148
1746-6148
DOI:10.1186/s12917-019-1929-2