The Value of IgM Memory B-Cells in the Assessment of Splenic Function in Childhood Cancer Survivors at Risk for Splenic Dysfunction: A DCCSS-LATER Study

Background. Childhood cancer survivors (CCS) who received radiotherapy involving the spleen or total body irradiation (TBI) might be at risk for splenic dysfunction. A comprehensive screening test for examining splenic dysfunction is lacking. Objective. We investigated whether IgM memory B-cells cou...

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Bibliographic Details
Published in:Journal of immunology research 2023-10, Vol.2023, p.1-8
Main Authors: Houtman, Bente M., Walraven, Iris, de Grouw, Elke, van der Maazen, Richard W. M., Kremer, Leontien C. M., van Dulmen-den Broeder, Eline, van den Heuvel-Eibrink, Marry M., Tissing, Wim J. E., Bresters, Dorine, van der Pal, Helena J. H., de Vries, Andrica C. H., Louwerens, Marloes, van der Heiden-van der Loo, Margriet, Neggers, Sebastian J. C., Janssens, Geert O., Blijlevens, Nicole M. A., Lambeck, Annechien J. A., Preijers, Frank, Loonen, Jacqueline J.
Format: Article
Language:English
Subjects:
Age
Cancer therapies
Children
Immunoglobulin M
Immunoglobulins
Immunological memory
Immunology
Infections
Leukemia
Lymphocytes B
Lymphoma
Memory cells
Patients
Radiation therapy
Software
Spleen
Splenectomy
Tumors
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Summary:Background. Childhood cancer survivors (CCS) who received radiotherapy involving the spleen or total body irradiation (TBI) might be at risk for splenic dysfunction. A comprehensive screening test for examining splenic dysfunction is lacking. Objective. We investigated whether IgM memory B-cells could be used to assess splenic dysfunction in CCS who received a splenectomy, radiotherapy involving the spleen, or TBI. Methods. All CCS were enrolled from the DCCSS-LATER cohort. We analyzed differences in IgM memory B-cells and Howell–Jolly bodies (HJB) in CCS who had a splenectomy (n = 9), received radiotherapy involving the spleen (n = 36), or TBI (n = 15). IgM memory B-cells 
ISSN:2314-8861
2314-7156
DOI:10.1155/2023/5863995