Dyslipidemia Diagnosis and Treatment: Risk Stratification in Children and Adolescents

Dyslipidemias or dyslipoproteinemias are quantitative changes in total cholesterol concentration, respective fractions, or triglycerides in the plasma. Evidence supported that dyslipidemia in childhood is associated with atherosclerosis in adulthood, and early identification and treatment potentiall...

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Published in:Journal of nutrition and metabolism 2022-02, Vol.2022, p.4782344-10
Main Authors: Mosca, Sara, Araújo, Graça, Costa, Vanessa, Correia, Joana, Bandeira, Anabela, Martins, Esmeralda, Mansilha, Helena, Tavares, Mónica, Coelho, Margarida P.
Format: Article
Language:English
Subjects:
Abdomen
Age
Apolipoproteins
Arteriosclerosis
Ataxia
Atherosclerosis
Cardiovascular disease
Cardiovascular diseases
Care and treatment
Children
Cholesterol
Cornea
Diagnosis
Dyslipidemia
Epigenetics
Families & family life
Fatty acids
Health aspects
Heart attacks
High density lipoprotein
Insulin resistance
Lipid metabolism
Lipids
Long-term effects
Low density lipoprotein receptors
Metabolism
Morbidity
Mutation
Pain
Pancreatitis
Pathogenesis
Pediatrics
Physiological aspects
Review
Risk factors
Teenagers
Triglycerides
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Araújo, Graça
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Tavares, Mónica
Coelho, Margarida P.
description Dyslipidemias or dyslipoproteinemias are quantitative changes in total cholesterol concentration, respective fractions, or triglycerides in the plasma. Evidence supported that dyslipidemia in childhood is associated with atherosclerosis in adulthood, and early identification and treatment potentially reduce cardiovascular risk in adulthood, which is the principal cause of morbidity and mortality in developed countries. Dyslipidemias can result from primary lipoprotein metabolism changes due to different genetic causes (primary dyslipidemias) or as a consequence of exogenous factors or other pathologies (secondary dyslipidemias). Therefore, the combined dyslipidemias result from the association of important epigenetic and environmental influences with risk factors for cardiovascular disease. The criterion for lipid metabolism screening at young ages is not widely accepted and possibly follows a universal or directed screening strategy. Additionally, little is known about its long-term effects or possible risk-benefit despite the growing tendency to start pharmacological therapy. Therefore, this study aimed to review the available bibliography on dyslipidemia in pediatric age to present a practical and structured approach to dyslipidemia that focuses on screening, risk stratification for atherosclerotic disease, and therapeutic approach.
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subjects Abdomen
Age
Apolipoproteins
Arteriosclerosis
Ataxia
Atherosclerosis
Cardiovascular disease
Cardiovascular diseases
Care and treatment
Children
Cholesterol
Cornea
Diagnosis
Dyslipidemia
Epigenetics
Families & family life
Fatty acids
Health aspects
Heart attacks
High density lipoprotein
Insulin resistance
Lipid metabolism
Lipids
Long-term effects
Low density lipoprotein receptors
Metabolism
Morbidity
Mutation
Pain
Pancreatitis
Pathogenesis
Pediatrics
Physiological aspects
Review
Risk factors
Teenagers
Triglycerides
title Dyslipidemia Diagnosis and Treatment: Risk Stratification in Children and Adolescents
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