Integrated Cobaloxime and Mesoporous Silica-Supported Ruthenium/Diamine Co-Catalysis for One-Pot Hydration/Reduction Enantioselective Sequential Reaction of Alkynes

This study developed a cost-efficient hydration/asymmetric transfer hydrogenation (ATH) process for the one-pot synthesis of valuable chiral alcohols from alkynes. During this process, the initial homogeneous cobaloxime-catalyzed hydration of alkynes was followed by heterogeneous Ru/diamine-catalyze...

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Bibliographic Details
Published in:Frontiers in chemistry 2021-09, Vol.9, p.732542-732542
Main Authors: Liu, Zeyang, Wang, Yongjie, Liu, Kaihong, Wang, Shanshan, Liao, Haocheng, Zhu, Yuanli, Hou, Baoming, Tan, Chunxia, Liu, Guohua
Format: Article
Language:English
Subjects:
asymmetric catalysis
Chemistry
heterogeneous catalysts
hydration
silica
transfer hydrogenation
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Summary:This study developed a cost-efficient hydration/asymmetric transfer hydrogenation (ATH) process for the one-pot synthesis of valuable chiral alcohols from alkynes. During this process, the initial homogeneous cobaloxime-catalyzed hydration of alkynes was followed by heterogeneous Ru/diamine-catalyzed ATH transformation of the generated ketones, which provided varieties of chiral alcohols in good yields with up to 99% values. The immobilized Ru/diamine catalyst could be recycled at least three times before its deactivation in the sequential reaction system. This work shows a general method for developing one-pot asymmetric sequential catalysis towards sustainable organic synthesis.
ISSN:2296-2646
2296-2646
DOI:10.3389/fchem.2021.732542