Antifungal Susceptibility Testing of Fusarium: A Practical Approach

In vitro susceptibility testing of is becoming increasingly important because of frequency and diversity of infections and because resistance profiles are species-specific. Reference methods for antifungal susceptibility testing (AFST) are those of Clinical and Laboratory Standards Institute (CLSI)...

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Bibliographic Details
Published in:Journal of fungi (Basel) 2017-04, Vol.3 (2), p.19
Main Authors: Al-Hatmi, Abdullah M S, Curfs-Breuker, Ilse, de Hoog, G Sybren, Meis, Jacques F, Verweij, Paul E
Format: Article
Language:English
Subjects:
Breakpoints
clinical laboratory
CLSI
Epidemiology
Etest
EUCAST
Fungi
Fusarium
Hospitals
Identification
Infections
Infectious diseases
Laboratories
Methods
Morphology
Peptides
Phylogeny
Proteins
Review
RNA polymerase
Species
Substance abuse treatment
susceptibility test
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Summary:In vitro susceptibility testing of is becoming increasingly important because of frequency and diversity of infections and because resistance profiles are species-specific. Reference methods for antifungal susceptibility testing (AFST) are those of Clinical and Laboratory Standards Institute (CLSI) and European Committee on Antimicrobial Susceptibility (EUCAST), but breakpoints (BPs) have not yet been established. One of the problems is that phylogenetic distances between species are much smaller than between species of, e.g., . Epidemiological cutoff values (ECVs) for some species have been determined in order to differentiate wild-type from non-wild-type isolates. In clinical routine, commercially available assays such as Etest, Sensititre or others provide essential agreement with reference methods. Our objective is to summarize antifungal susceptibility testing of genus in the clinical laboratory: how to do it, when to do it, and how to interpret it.
ISSN:2309-608X
2309-608X
DOI:10.3390/jof3020019