Antibacterial activity of cobalt(II) complexes with some benzimidazole derivatives

• Published in: Journal of the Serbian Chemical Society 2008-01, Vol.73 (12), p.1153-1160
• Main Authors: Podunavac-Kuzmanovic, S.O., Leovac, V.M., Cvetkovic, D.D.
• Format: Article
• Language: English
• Subjects: antibacterial; benzimidazole derivatives; cobalt(II); complexes; in vitro studies
• ISSN: 0352-5139; 1820-7421
• DOI: 10.2298/JSC0812153P

The antibacterial activities of cobalt(II) complexes with two series of benzimidazoles were evaluated in vitro against three Gram-positive bacterial strains (Bacillus cereus, Staphylococcus aureus, and Sarcina lutea) and one Gram-negative isolate (Pseudomonas aeruginosa). The minimum inhibitory concentration was determined for all the complexes. The majority of the investtigated complexes displayed in vitro inhibitory activity against very persistent bacteria. They were found to be more active against Gram-positive than Gram-negative bacteria. It may be concluded that the antibacterial activity of the compounds is related to the cell wall structure of the tested bacteria. Comparing the inhibitory activities of the tested complexes, it was found that the 1-substituted- -2-aminobenzimidazole derivatives were more active than complexes of 1-substituted- 2-amino-5,6-dimethylbenzimidazoles. The effect of chemical structure on the antibacterial activity is discussed. Ispitana je in vitro antibakterijska aktivnost kobalt(II) kompleksa sa dve serije benzimidazola prema tri gram-pozitivne bakterije (Bacillus cereus, Staphylococcus aureus i Sarcina lutea) i jednoj gram-negativnoj bakteriji (Pseudomonas aeruginosa). Za sve komplekse odredjena je minimalna inhibitorna koncentracija. Vecina ispitivanih kompleksa pokazala je in vitro inhibitornu aktivnost prema veoma otpornim bakterijama. Utvrdjeno je da ispitivani kompleksi pokazuju vecu aktivnost prema gram-pozitivnim nego prema gram-negativnoj bakteriji, sto ukazuje na to da antibakterijska aktivnost jedinjenja zavisi od gradje celijskog zida. Poredjenjem inhibitorne aktivnosti testiranih kompleksa doslo se do zakljucka da su kompleksi derivata 1-supstituisanih-2-aminobenzimidazola aktivniji od derivata 1-supstituisanih-2-amino-5,6-dimetilbenzimidazola. Prodiskutovan je uticaj hemijske strukture na antibakterijsku aktivnost.