Association of Biomarkers for Dyslipidemia, Inflammation, and Oxidative Stress with Endothelial Dysfunction in Obese Youths: A Case-Control Study

• Published in: Diabetes, metabolic syndrome and obesity metabolic syndrome and obesity, 2024-06, Vol.17, p.2533-2545
• Main Authors: Sharma, Charu, Suliman, Abubaker, Al Hamad, Sania Mazin, Yasin, Javed, Abuzakouk, Mohamed, AlKaabi, Juma, Aburawi, Elhadi Husein
• Format: Article
• Language: English
• Subjects: and oxidative stress; Biological markers; Cardiovascular diseases; Children; dyslipidemia; endothelial dysfunction; Endothelium; Ethylenediaminetetraacetic acid; Ferritin; Glycosylated hemoglobin; Health aspects; Inflammation; Medical research; Medicine, Experimental; Nitric oxide; obesity; Obesity in adolescence; Original Research; Oxidative stress; Risk factors; Teenagers; Type 2 diabetes; Youth
• ISSN: 1178-7007; 1178-7007
• DOI: 10.2147/DMSO.S458233

The United Arab Emirates (UAE), with its characteristic local population, geography, and history, presents several risk factors for cardiovascular diseases (CVDs) in obese individuals. Obesity and its associated complications, including diabetes, atherogenic dyslipidemia, and CVDs leading to significant health risks. In the present study, "Youths" defined as young people between 18 and 22 years. We assessed dyslipidemia, inflammation, and oxidative stress biomarker levels and their association with endothelial dysfunction (ED) in both overweight/obese and normal weight youths of UAE. There were 160 youths with overweight/obese (BMI ≥ 25 kg/m ) patients and healthy age- and sex-matched normal weight (BMI ≤ 24.9 kg/m ) as controls participated in this study. The anthropometric data and blood samples were collected to assess the biomarkers for dyslipidemia, inflammation, oxidative stress, ED from all the youths. The overall mean age and male-to-female ratio were 20±1.5years and 1.0:1.2, respectively. There was statistically significant difference in HDL-C (p