Analysis of neonatal mortality risk factors in Brazil: a systematic review and meta-analysis of observational studies

To identify, using a systematic review and meta-analysis of observational studies, which risk factors are significantly associated with neonatal mortality in Brazil, and to build a comprehensive national analysis on neonatal mortality. This review included observational studies on neonatal mortality...

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Bibliographic Details
Published in:Jornal de pediatria 2019-09, Vol.95 (5), p.519-530
Main Authors: Veloso, Felipe Camilo Santiago, Kassar, Liliana de Meira Lins, Oliveira, Michelle Jacintha Cavalcante, Lima, Telmo Henrique Barbosa de, Bueno, Nassib Bezerra, Gurgel, Ricardo Queiroz, Kassar, Samir Buainain
Format: Article
Language:English
Subjects:
Brasil
Brazil
Brazil - epidemiology
Fatores de risco
Female
Humans
Infant
Infant Mortality
Infant, Low Birth Weight
Infant, Premature
Meta-analysis
Metanálise
Mortalidade neonatal
Neonatal mortality
Observational Studies as Topic
PEDIATRICS
Pregnancy
Pregnancy Complications
Review systematic
Revisão sistemática
Risk Assessment
Risk Factors
Socioeconomic Factors
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Summary:To identify, using a systematic review and meta-analysis of observational studies, which risk factors are significantly associated with neonatal mortality in Brazil, and to build a comprehensive national analysis on neonatal mortality. This review included observational studies on neonatal mortality, performed between 2000 and 2018 in Brazilian cities. The MEDLINE, Elsevier, Cochrane, LILACS, SciELO, and OpenGrey databases were used. For the qualitative analysis, the Newcastle-Ottawa Scale was used. For the quantitative analysis, the natural logarithms of the risk measures and their confidence intervals were used, as well as the DerSimonian and Laird method as a random effects model, and the Mantel–Haenszel model for heterogeneity estimation. A confidence level of 95% was considered. The qualitative analysis resulted in six studies of low and four studies of intermediate-low bias risk. The following exposure factors were significant: absence of partner, maternal age ≥35 years, male gender, multiple gestation, inadequate and absent prenatal care, presence of complications during pregnancy, congenital malformation in the assessed pregnancy, Apgar
ISSN:0021-7557
1678-4782
1678-4782
DOI:10.1016/j.jped.2018.12.014