Neurohormonal activation pattern in patients with atrial septal defect

• Published in: Scientific reports 2024-12, Vol.14 (1), p.29980-9, Article 29980
• Main Authors: Çetin Güvenç, Rengin, Koç Ada, Saniye, Güvenç, Tolga Sinan, Çelik, Fatma Betül, Polat Ocaklı, Ezgi, Al Arfaj, Abdullah Ayar, Güllü, Hakan, Özer, Nihat, Çekmen, Mustafa Baki, Çalışkan, Mustafa
• Format: Article
• Language: English
• Subjects: 631/45/776; 692/4019/592/75/1539; Adult; Aldosterone; Aldosterone - blood; Argipressin; Atrial septal defect; Blood; Cardiac arrhythmia; Cardiovascular disease; Case-Control Studies; Congenital diseases; Endothelin; Endothelin 1; Endothelin-1 - blood; Female; Glycopeptides - blood; Heart failure; Heart Septal Defects, Atrial - blood; Heart Septal Defects, Atrial - physiopathology; Humanities and Social Sciences; Humans; Laboratories; Male; Middle Aged; multidisciplinary; Natriuretic Peptide, Brain - blood; Neurohormonal activation; Neurotransmitter Agents - blood; Neurotransmitter Agents - metabolism; Neurotransmitters; Noradrenaline; Norepinephrine; Norepinephrine - blood; Peptides; Plasma; Pulmonary arteries; Pulmonary hypertension; Renin; Renin - blood; Science; Science (multidisciplinary); Vasoconstriction; Vasopressin
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-78950-x

Atrial septal defects (ASD) divert flow from systemic to pulmonary circulation, and some degree of plasma volume expansion and neurohormonal activation are necessary to maintain the effective circulatory volume. The aim of the present study was to understand the patterns of neurohormonal activation in ASD patients. 16 ASD patients and 10 controls were enrolled. Fasting blood samples were collected prior to procedure and 48 h after defect closure. At baseline, renin (185.0(79.0—437.0 vs. 79.4(60.8—110.0),  p  = 0.04), aldosterone (20.2 ± 7.6 vs. 11.7 ± 2.8,  p