Defining the pediatric response to SARS-CoV-2 variants

The global population has been severely affected by the coronavirus disease 2019 (COVID-19) pandemic, however, with older age identified as a risk factor, children have been underprioritized. This article discusses the factors contributing to the less severe response observed in children following i...

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Bibliographic Details
Published in:Frontiers in immunology 2023-05, Vol.14, p.1200456-1200456
Main Authors: Ho, Reanne M, Bowen, Asha C, Blyth, Christopher C, Imrie, Allison, Kollmann, Tobias R, Stick, Stephen M, Kicic, Anthony
Format: Article
Language:English
Subjects:
Child
children
COVID-19
emerging variants
Humans
Immunology
molecular biology
Pandemics
pediatric
Receptors, Virus
SARS-CoV-2
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Summary:The global population has been severely affected by the coronavirus disease 2019 (COVID-19) pandemic, however, with older age identified as a risk factor, children have been underprioritized. This article discusses the factors contributing to the less severe response observed in children following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including, differing viral entry receptor expression and immune responses. It also discusses how emerging and future variants could present a higher risk to children, including those with underlying comorbidities, in developing severe disease. Furthermore, this perspective discusses the differential inflammatory markers between critical and non-critical cases, as well as discussing the types of variants that may be more pathogenic to children. Importantly, this article highlights where more research is urgently required, in order to protect the most vulnerable of our children.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2023.1200456