Activities of Some Medicinal Plants on the Proliferation and Invasion of Brain Tumor Cell Lines

Cancer is a debilitating disease that is on the increase in both developed and developing countries. Anticancer drugs are often expensive, have narrow spectrum of activities, and are associated with toxicities and side effects such as myelosuppression, immunosuppression, gastrointestinal disturbance...

Full description

Saved in:
Bibliographic Details
Published in:Advances in pharmacological and pharmaceutical sciences 2020, Vol.2020 (2020), p.1-7
Main Authors: Zhang, Ying, Abounader, Roger, Sandabe, Umar K., Ngulde, Saidu I., Hussaini, Isa M.
Format: Article
Language:English
Subjects:
Brain cancer
Collagen
Herbal medicine
Pharmaceutical sciences
Pharmacology
Sodium
Variance analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cancer is a debilitating disease that is on the increase in both developed and developing countries. Anticancer drugs are often expensive, have narrow spectrum of activities, and are associated with toxicities and side effects such as myelosuppression, immunosuppression, gastrointestinal disturbance, alopecia, skin toxicity, and hepatotoxicity. Plants have been the major source of anticancer drugs both in orthodox and traditional medicine. Many of the plants claimed by the traditional medicine practitioners (TMPs) to be effective in the treatment of cancer are yet to be evaluated scientifically. In this work, five medicinal plants used by TMPs in Borno State, Nigeria, were tested against two brain tumor cell lines. Ethanol extracts of Securidaca longepedunculata, Andira inermis subsp. rooseveltii, Annona senegalensis, Carissa edulis, and Parinari polyandra were used. U87 and U231 brain tumor cell lines were used for proliferation assay, U251 cell line was used for the invasion assay in collagen V coated inserts, and U87 cell line was used for the western blot detection of cleaved Poly-ADP-Ribose-Polymerase (PARP). The result revealed that all tested extracts significantly (p
ISSN:2633-4682
2633-4690
DOI:10.1155/2020/3626879