A comparison of various methods for measuring breast density and breast tissue composition in adolescent girls and women

This study compared different approaches to measuring breast density and breast tissue composition (BTC) in adolescent girls (n = 42, aged 14–16 years) and their mothers (n = 39, aged 36–61 years) from a cohort in Santiago, Chile. Optical spectroscopy (OS) was used to measure collagen, water, and li...

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Bibliographic Details
Published in:Scientific reports 2022-08, Vol.12 (1), p.13547-13547, Article 13547
Main Authors: Kehm, Rebecca D., Walter, E. Jane, Pereira, Ana, White, Melissa L., Oskar, Sabine, Michels, Karin B., Shepherd, John A., Lilge, Lothar, Terry, Mary Beth
Format: Article
Language:English
Subjects:
631/67/1347
631/67/2195
631/67/2322
Absorptiometry, Photon - methods
Adolescent
Adolescents
Body mass index
Breast - diagnostic imaging
Breast cancer
Breast Density
Breast Neoplasms - diagnostic imaging
Collagen
Correlation coefficient
Digitizing
Dual energy X-ray absorptiometry
Female
Girls
Health risks
Humanities and Social Sciences
Humans
Mammography
Mammography - methods
multidisciplinary
Science
Science (multidisciplinary)
Spectroscopy
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Summary:This study compared different approaches to measuring breast density and breast tissue composition (BTC) in adolescent girls (n = 42, aged 14–16 years) and their mothers (n = 39, aged 36–61 years) from a cohort in Santiago, Chile. Optical spectroscopy (OS) was used to measure collagen, water, and lipid concentrations, which were combined into a percent breast density index (%BDI). A clinical dual-energy X-ray absorptiometry (DXA) system calibrated to measure breast density provided percent fibroglandular volume (%FGV) from manually delineated images. After digitizing mammogram films, the percent mammographic breast density (%MBD) was measured using computer-assisted software. Partial correlation coefficients ( r partial ) were used to evaluate associations between breast density measures and BTC from these three different measurement approaches, adjusting for age and body mass index. %BDI from OS was associated with %FGV from DXA in adolescent girls ( r partial  = 0.46, p -value = 0.003), but not in mothers ( r partial  = 0.17, p -value = 0.32). In mothers, %FGV from DXA was associated with %MBD from mammograms ( r partial  = 0.60, p -value 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-17800-0