Immunosuppressive Properties of Epidermal Keratinocytes Differ According to Their Immaturity Status

Preservation of a functional keratinocyte stem cell pool is essential to ensure the long-term maintenance of epidermis integrity, through continuous physiological renewal and regeneration in case of injury. Protecting stem cells from inflammation and immune reactions is thus a critical issue that ne...

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Bibliographic Details
Published in:Frontiers in immunology 2022-02, Vol.13, p.786859-786859
Main Authors: Mestrallet, Guillaume, Carosella, Edgardo D, Martin, Michele T, Rouas-Freiss, Nathalie, Fortunel, Nicolas O, LeMaoult, Joel
Format: Article
Language:English
Subjects:
CD4+ T-cell proliferation
Epidermis
ErbB Receptors
HLA-G
Humans
Immunology
immunosuppression
Inflammation
Integrin alpha6
keratinocyte stem cells
Keratinocytes
Life Sciences
PD-L1
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Summary:Preservation of a functional keratinocyte stem cell pool is essential to ensure the long-term maintenance of epidermis integrity, through continuous physiological renewal and regeneration in case of injury. Protecting stem cells from inflammation and immune reactions is thus a critical issue that needs to be explored. Here, we show that the immature CD49f precursor cell fraction from interfollicular epidermis keratinocytes, comprising stem cells and progenitors, is able to inhibit CD4 T-cell proliferation. Of note, both the stem cell-enriched CD49f /EGFR subpopulation and the less immature CD49f /EGFR progenitors ensure this effect. Moreover, we show that HLA-G and PD-L1 immune checkpoints are overexpressed in CD49f precursors, as compared to CD49f differentiated keratinocytes. This potency may limit immune reactions against immature precursors including stem cells, and protect them from exacerbated inflammation. Further exploring this correlation between immuno-modulation and immaturity may open perspectives in allogenic cell therapies.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.786859