Mast cells and factor XIIIa+ dendrocytes in actinic cheilitis and lip squamous cell carcinoma

There is an interaction between dendrocytes and mast cells in the skin. However, in elastosis-related diseases such as actinic cheilitis (AC) and lower lip squamous cell carcinoma (LLSCC), this interaction remains unknown. We investigated the presence of intact and degranulated mast cells in AC and...

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Published in:Brazilian oral research 2024, Vol.38, p.e113
Main Authors: Flores, Isadora Luana, de Arruda, José Alcides Almeida, Abrantes, Thamiris de Castro, Gamba, Thiago de Oliveira, Abrahão, Aline Correa, Anbinder, Ana Lia, Ribeiro, Jaqueline Lemes, Vasconcelos, Ana Carolina Uchoa, Andrade, Bruno Augusto Benevenuto de, Aguiar, Maria Cassia Ferreira de, Gomes, Ana Paula Neutzling, Abreu, Lucas Guimarães, Mesquita, Ricardo Alves
Format: Article
Language:English
Subjects:
Adult
Aged
Carcinoma, Squamous Cell
Carcinoma, Squamous Cell - pathology
Case-Control Studies
Cell Count
Cell Degranulation
Cheilitis - pathology
Dendritic Cells - pathology
Factor XIIIa
Female
Humans
Immunohistochemistry
Lip Neoplasms - pathology
Male
Mast Cells
Mast Cells - pathology
Middle Aged
Mouth Mucosa - pathology
Original Research/Oral Pathology
Reference Values
Statistics, Nonparametric
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container_title Brazilian oral research
container_volume 38
creator Flores, Isadora Luana
de Arruda, José Alcides Almeida
Abrantes, Thamiris de Castro
Gamba, Thiago de Oliveira
Abrahão, Aline Correa
Anbinder, Ana Lia
Ribeiro, Jaqueline Lemes
Vasconcelos, Ana Carolina Uchoa
Andrade, Bruno Augusto Benevenuto de
Aguiar, Maria Cassia Ferreira de
Gomes, Ana Paula Neutzling
Abreu, Lucas Guimarães
Mesquita, Ricardo Alves
description There is an interaction between dendrocytes and mast cells in the skin. However, in elastosis-related diseases such as actinic cheilitis (AC) and lower lip squamous cell carcinoma (LLSCC), this interaction remains unknown. We investigated the presence of intact and degranulated mast cells in AC and LLSCC. Associations of mast cells with factor XIIIa+ dendrocytes and inflammatory infiltrate were assessed. Forty cases of AC (20 with low-grade and 20 with high-grade epithelial dysplasia), 50 cases of LLSCC, and 10 cases of normal oral mucosa were evaluated. Toluidine blue staining was performed to identify mast cells, and mast cell densities were calculated in the inflammatory infiltrate. Factor XIIIa+ dendrocytes were immunohistochemically quantified. The highest ratio of intact/degranulated mast cells density was detected in LLSCC (5.9 cells/mm2), followed by AC with high-grade epithelial dysplasia (4.8 cells/mm2). Statistically significant differences were found in the density of intact mast cells compared to degranulated mast cells in AC with low-grade epithelial dysplasia (p
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However, in elastosis-related diseases such as actinic cheilitis (AC) and lower lip squamous cell carcinoma (LLSCC), this interaction remains unknown. We investigated the presence of intact and degranulated mast cells in AC and LLSCC. Associations of mast cells with factor XIIIa+ dendrocytes and inflammatory infiltrate were assessed. Forty cases of AC (20 with low-grade and 20 with high-grade epithelial dysplasia), 50 cases of LLSCC, and 10 cases of normal oral mucosa were evaluated. Toluidine blue staining was performed to identify mast cells, and mast cell densities were calculated in the inflammatory infiltrate. Factor XIIIa+ dendrocytes were immunohistochemically quantified. The highest ratio of intact/degranulated mast cells density was detected in LLSCC (5.9 cells/mm2), followed by AC with high-grade epithelial dysplasia (4.8 cells/mm2). Statistically significant differences were found in the density of intact mast cells compared to degranulated mast cells in AC with low-grade epithelial dysplasia (p&lt;0.001), AC with high-grade epithelial dysplasia (p=0.005), and LLSCC (p&lt;0.001). A positive correlation between degranulated mast cells and total inflammatory infiltrate (p=0.03) was observed in the LLSCC group. The expression of factor XIIIa+ dendrocytes was highest in AC with low-grade epithelial dysplasia (16.5 cells/mm2). 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Statistically significant differences were found in the density of intact mast cells compared to degranulated mast cells in AC with low-grade epithelial dysplasia (p&lt;0.001), AC with high-grade epithelial dysplasia (p=0.005), and LLSCC (p&lt;0.001). A positive correlation between degranulated mast cells and total inflammatory infiltrate (p=0.03) was observed in the LLSCC group. The expression of factor XIIIa+ dendrocytes was highest in AC with low-grade epithelial dysplasia (16.5 cells/mm2). 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However, in elastosis-related diseases such as actinic cheilitis (AC) and lower lip squamous cell carcinoma (LLSCC), this interaction remains unknown. We investigated the presence of intact and degranulated mast cells in AC and LLSCC. Associations of mast cells with factor XIIIa+ dendrocytes and inflammatory infiltrate were assessed. Forty cases of AC (20 with low-grade and 20 with high-grade epithelial dysplasia), 50 cases of LLSCC, and 10 cases of normal oral mucosa were evaluated. Toluidine blue staining was performed to identify mast cells, and mast cell densities were calculated in the inflammatory infiltrate. Factor XIIIa+ dendrocytes were immunohistochemically quantified. The highest ratio of intact/degranulated mast cells density was detected in LLSCC (5.9 cells/mm2), followed by AC with high-grade epithelial dysplasia (4.8 cells/mm2). 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subjects Adult
Aged
Carcinoma, Squamous Cell
Carcinoma, Squamous Cell - pathology
Case-Control Studies
Cell Count
Cell Degranulation
Cheilitis - pathology
Dendritic Cells - pathology
Factor XIIIa
Female
Humans
Immunohistochemistry
Lip Neoplasms - pathology
Male
Mast Cells
Mast Cells - pathology
Middle Aged
Mouth Mucosa - pathology
Original Research/Oral Pathology
Reference Values
Statistics, Nonparametric
title Mast cells and factor XIIIa+ dendrocytes in actinic cheilitis and lip squamous cell carcinoma
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