Chemotherapy Induced Corneal Changes Assessed by Corneal Confocal Microscopy: A Review

The eye, and the cornea in particular, is a common site of chemotherapy induced toxicity, and ocular side effects of both traditional and novel agents have been reported. Corneal confocal microscopy (CCM) is an in vivo technique that allows for the study of all the corneal layers in an easy, non-inv...

Full description

Saved in:
Bibliographic Details
Published in:Diagnostics (Basel) 2024-10, Vol.14 (21), p.2399
Main Authors: Cosmo, Eleonora, Midena, Giulia, Parrozzani, Raffaele, Midena, Edoardo
Format: Article
Language:English
Subjects:
Antimitotic agents
Antineoplastic agents
Cancer
Cancer therapies
Chemotherapy
Cornea
corneal confocal microscopy
corneal epithelium
corneal toxicity
Dendritic cells
Diabetic neuropathy
Drug dosages
Microscope and microscopy
Microscopy
Nervous system
Peripheral neuropathy
Review
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The eye, and the cornea in particular, is a common site of chemotherapy induced toxicity, and ocular side effects of both traditional and novel agents have been reported. Corneal confocal microscopy (CCM) is an in vivo technique that allows for the study of all the corneal layers in an easy, non-invasive and reproducible way via the direct visualization of corneal cell morphologies as well as of sub-basal nerve plexus. Thus, it represents a useful way to identify and monitor chemotherapy induced corneal alterations. This work aims to review the use of CCM in identifying corneal toxicity secondary to chemotherapy treatment, as regards both corneal nerves alterations in the setting of chemotherapy induced peripheral neuropathy (CIPN) and other corneal structure changes, particularly involving the corneal epithelium.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics14212399