Loading…

Screening tools for predicting mortality of adults with suspected sepsis: an international sepsis cohort validation study

ObjectivesWe evaluated the performance of commonly used sepsis screening tools across prospective sepsis cohorts in the USA, Cambodia and Ghana.DesignProspective cohort studies.Setting and participantsFrom 2014 to 2021, participants with two or more SIRS (Systemic Inflammatory Response Syndrome) cri...

Full description

Saved in:
Bibliographic Details
Published in:BMJ open 2023-02, Vol.13 (2), p.e067840-e067840
Main Authors: Blair, Paul W, Mehta, Rittal, Oppong, Chris Kwaku, Tin, Som, Ko, Emily, Tsalik, Ephraim L, Chenoweth, Josh, Rozo, Michelle, Adams, Nehkonti, Beckett, Charmagne, Woods, Christopher W, Striegel, Deborah A, Salvador, Mark G, Brandsma, Joost, McKean, Lauren, Mahle, Rachael E, Hulsey, William R, Krishnan, Subramaniam, Prouty, Michael, Letizia, Andrew, Fox, Anne, Faix, Dennis, Lawler, James V, Duplessis, Chris, Gregory, Michael G, Vantha, Te, Owusu-Ofori, Alex Kwame, Ansong, Daniel, Oduro, George, Schully, Kevin L, Clark, Danielle V
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ObjectivesWe evaluated the performance of commonly used sepsis screening tools across prospective sepsis cohorts in the USA, Cambodia and Ghana.DesignProspective cohort studies.Setting and participantsFrom 2014 to 2021, participants with two or more SIRS (Systemic Inflammatory Response Syndrome) criteria and suspected infection were enrolled in emergency departments and medical wards at hospitals in Cambodia and Ghana and hospitalised participants with suspected infection were enrolled in the USA. Cox proportional hazards regression was performed, and Harrell’s C-statistic calculated to determine 28-day mortality prediction performance of the quick Sequential Organ Failure Assessment (qSOFA) score ≥2, SIRS score ≥3, National Early Warning Score (NEWS) ≥5, Modified Early Warning Score (MEWS) ≥5 or Universal Vital Assessment (UVA) score ≥2. Screening tools were compared with baseline risk (age and sex) with the Wald test.ResultsThe cohorts included 567 participants (42.9% women) including 187 participants from Kumasi, Ghana, 200 participants from Takeo, Cambodia and 180 participants from Durham, North Carolina in the USA. The pooled mortality was 16.4% at 28 days. The mortality prediction accuracy increased from baseline risk with the MEWS (C-statistic: 0.63, 95% CI 0.58 to 0.68; p=0.002), NEWS (C-statistic: 0.68; 95% CI 0.64 to 0.73; p
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2022-067840