The Role of MicroRNAs in the Pathogenesis of Diabetic Nephropathy

Diabetic nephropathy (DN) is one of the most common microvascular complications in diabetic patients; it is also an important cause of renal dysfunction, renal fibrosis, and end-stage renal disease. Unfortunately, the pathogenesis of DN is complex and has not yet been fully elucidated; hence, the pa...

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Bibliographic Details
Published in:International journal of endocrinology 2019, Vol.2019 (2019), p.1-8
Main Authors: Wang, Linjia, Chen, Xing, Yan, Haiying, Yao, Deyi, Tang, Jian, Zhan, Huakui
Format: Article
Language:English
Subjects:
Apoptosis
Binding sites
Biomarkers
Cell growth
Chronic kidney failure
Collagen
Cytokines
Development and progression
Diabetes
Diabetic nephropathies
Diabetic nephropathy
Diabetics
Disease
Endocrinology
Glucose
Health aspects
Inflammation
Kidneys
Medical research
Medicine, Experimental
Metabolism
MicroRNA
MicroRNAs
Oxidative stress
Pathogenesis
Review
Type 2 diabetes
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Summary:Diabetic nephropathy (DN) is one of the most common microvascular complications in diabetic patients; it is also an important cause of renal dysfunction, renal fibrosis, and end-stage renal disease. Unfortunately, the pathogenesis of DN is complex and has not yet been fully elucidated; hence, the pathogenesis of DN to determine effective treatments of crucial importance is deeply explored. Early DN research focuses on hemodynamic changes and metabolic disorders, and recent studies have shown the regulatory role of microRNAs (miRNAs) in genes, which may be a new diagnostic marker and therapeutic target for diabetic nephropathy. In this review, we summarize the recent advances in the clinical value and molecular mechanisms of miRNAs in DN, providing new ideas for the diagnosis and treatment of DN.
ISSN:1687-8337
1687-8345
DOI:10.1155/2019/8719060