Sudden Infant Death Syndrome, Infection, Prone Sleep Position, and Vagal Neuroimmunology

Recent findings suggest that infection (and sepsis) stand alone as the only plausible mechanism of causation of sudden infant death syndrome (SIDS) and accordingly achieves congruence with all clinicopathological and epidemiological findings. This review examines the role of infection in the pathoge...

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Bibliographic Details
Published in:Frontiers in pediatrics 2017-11, Vol.5, p.223-223
Main Author: Goldwater, Paul Nathan
Format: Article
Language:English
Subjects:
infection
neuroimmunology
Pediatrics
prone sleep position
sudden infant death syndrome
vagus
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Summary:Recent findings suggest that infection (and sepsis) stand alone as the only plausible mechanism of causation of sudden infant death syndrome (SIDS) and accordingly achieves congruence with all clinicopathological and epidemiological findings. This review examines the role of infection in the pathogenesis of SIDS in the context of the major risk factor of prone sleep position. The study explores how sleep position could interact with the immune system and inflammatory response vagal neural connections, which could play key roles in gut and immune homeostasis. A plausible and congruent clinicopathological and epidemiological paradigm is suggested.
ISSN:2296-2360
2296-2360
DOI:10.3389/fped.2017.00223