Vascular volume changes in radiological patterns of usual interstitial pneumonia in patients with type 2 diabetes

• Published in: Diabetology and metabolic syndrome 2024-12, Vol.16 (1), p.298-9
• Main Authors: Wang, Jiarong, Li, Yuanchao, Chen, Hao, Wang, Jianbo
• Format: Article
• Language: English
• Subjects: Bacterial pneumonia; Care and treatment; Complications and side effects; CT imaging; Development and progression; Glycosylated hemoglobin; High-resolution computed tomography; Intrapulmonary vascular volume; Medical colleges; Pneumonia; Pulmonary fibrosis; Type 2 diabetes; Type 2 diabetes mellitus; Usual interstitial pneumonia
• ISSN: 1758-5996; 1758-5996
• DOI: 10.1186/s13098-024-01551-1

This research primarily focuses on exploring the changes in intrapulmonary vascular volume (IPVV) in radiological patterns of usual interstitial pneumonia (UIP) associated with Type 2 Diabetes Mellitus (T2DM), thereby inferring the possible mechanisms of the co-occurrence of diabetes and UIP patterns. Thin-layer data were post-processed on the basis of high-resolution computed tomography (HRCT) and quantitatively assessed for IPVV. Changes in IPVV were compared between T2DM combined with UIP modality and T2DM non-UIP modality. Correlations between UIP patterns and various markers and confounders, including IPVV, were determined via logistic regression analysis. In this study, the potential of IPVV as a predictor for UIP presence was analysed through the application of subject operating characteristic curve analysis. In patients with T2DM, the IPVV demonstrated smaller size in those with combined UIP patterns compared to T2DM patients without UIP patterns (164.4 ± 68.7 vs 202.9 ± 76.3 mL, P = 0.005). We detected a positive correlation between IPVV levels and several variables, including fasting plasma glucose (FPG) (r = 0.404, P