Comparative evaluation of the efficacy of two modes of delivery of diclofenac for the management of post-endodontic pain: A randomized controlled clinical trial

Background: This study aimed to compare the efficacy of two modes of delivery of diclofenac for the management of post-endodontic pain. Materials and Methods: This study comprised 30 patients reporting to the department with pain in their teeth. Pain was assessed using the visual analog scale (VAS):...

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Published in:Journal of pharmacy & bioallied science 2023-07, Vol.15 (6), p.1283-1286
Main Authors: Dheeraj, Munish, Johar, Suksham, Mahajan, Priya, Jandial, Tania, Chauhan, Shikha, Gupta, Kamakshi
Format: Article
Language:English
Subjects:
Analgesics
Care and treatment
Clinical trials
Diclofenac
endodontic pain
Medical research
Medicine, Experimental
Nonsteroidal anti-inflammatory drugs
Original
Pain
Patients
transdermal drug
Transdermal medication
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Summary:Background: This study aimed to compare the efficacy of two modes of delivery of diclofenac for the management of post-endodontic pain. Materials and Methods: This study comprised 30 patients reporting to the department with pain in their teeth. Pain was assessed using the visual analog scale (VAS): group A (control group), group B (oral diclofenac), and group C (transdermal patch). A VAS was given to the patients in each group, and the severity of any pain was self-assessed by patients after 4 hrs, 8 hrs, 12 hrs, 24 hrs, and 48 hrs following the completion of treatment. Results: A comparison between group oral and diclofenac transdermal patch was carried out. The pain frequency was measured at 4 hrs, 8 hrs, 12 hrs, 24 hrs, and 48 hrs postoperatively with P values of 0.744, 0.035, 0.570, 0.060, and 0.508 and was statistically insignificant. Conclusion: Preoperative analgesics play an important role in reducing post-endodontic pain. Transdermal patches containing diclofenac show a promising analgesic modality in managing endodontic pain.
ISSN:0975-7406
0976-4879
0975-7406
DOI:10.4103/jpbs.jpbs_119_23