Infliximab and etanercept are equally effective in reducing enterocyte APOPTOSIS in experimental colitis

Loss of epithelial barrier integrity is considered an early step in the pathogenesis of Crohn's disease (CD), and the rate of enterocyte apoptosis is one of the determinants of the intestinal barrier function. Tumor necrosis factor-alpha (TNF-alpha), one of the major proinflammatory mediators i...

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Bibliographic Details
Published in:International journal of medical sciences 2008-07, Vol.5 (4), p.169-180
Main Authors: Fries, Walter, Muja, Carmelo, Crisafulli, Carmela, Costantino, Giuseppe, Longo, Giuseppe, Cuzzocrea, Salvatore, Mazzon, Emanuela
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - pharmacology
Antibodies, Monoclonal - pharmacology
Apoptosis - drug effects
Benzenesulfonates
Blotting, Western
Colitis - chemically induced
Colitis - drug therapy
Colitis - physiopathology
Disease Models, Animal
Enterocytes - drug effects
Enterocytes - metabolism
Enterocytes - pathology
Etanercept
Fas Ligand Protein - metabolism
Immunoglobulin G - pharmacology
Immunohistochemistry
In Situ Nick-End Labeling
Infliximab
Male
Mice
Mice, Knockout
Proto-Oncogene Proteins c-bcl-2 - metabolism
Receptors, Tumor Necrosis Factor
Receptors, Tumor Necrosis Factor, Type I - genetics
Receptors, Tumor Necrosis Factor, Type I - physiology
Research Paper
Tumor Necrosis Factor-alpha - blood
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Summary:Loss of epithelial barrier integrity is considered an early step in the pathogenesis of Crohn's disease (CD), and the rate of enterocyte apoptosis is one of the determinants of the intestinal barrier function. Tumor necrosis factor-alpha (TNF-alpha), one of the major proinflammatory mediators in CD, is one of the extrinsic signals which initiate apoptosis of enterocytes. The aim of this study was to investigate the early effects of experimental colitis on enterocyte apoptosis, and the effects of two anti-TNF treatments, infliximab (IFX) and etanercept (ETC). In addition, the importance of receptor I for TNF was tested in TNFR-1(-/- )mice. Circulating TNF-alpha levels were effectively reduced by IFX and ETC (p
ISSN:1449-1907
1449-1907
DOI:10.7150/ijms.5.169