The Mediterranean Diet as a Source of Bioactive Molecules with Cannabinomimetic Activity in Prevention and Therapy Strategy

The endocannabinoid system is a complex lipid signaling network that has evolved to be a key regulator of pro-homeostatic pathways for the organism. Its involvement in numerous processes has rendered it a very suitable target for pharmacological studies regarding metabolic syndrome, obesity and othe...

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Bibliographic Details
Published in:Nutrients 2022-01, Vol.14 (3), p.468
Main Authors: Vago, Riccardo, Fiorio, Francesco, Trevisani, Francesco, Salonia, Andrea, Montorsi, Francesco, Bettiga, Arianna
Format: Article
Language:English
Subjects:
Analgesics
Binding sites
Body fat
Cannabinoid CB1 receptors
Cannabinoid CB2 receptors
Diet
Diet, Mediterranean
Dietary intake
Endocannabinoid system
Endocannabinoids - metabolism
Enzymes
Fatty acids
Food
Humans
Lifestyles
Ligands
Lipids
Marijuana
Mediterranean diet
Metabolic disorders
Metabolic syndrome
Nutrition
Obesity - prevention & control
Oils & fats
personalized nutrition
polyphenols
Prevention
Review
terpenes
Therapeutic targets
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Summary:The endocannabinoid system is a complex lipid signaling network that has evolved to be a key regulator of pro-homeostatic pathways for the organism. Its involvement in numerous processes has rendered it a very suitable target for pharmacological studies regarding metabolic syndrome, obesity and other lifestyle-related diseases. Cannabinomimetic molecules have been found in a large variety of foods, most of which are normally present in the Mediterranean diet. The majority of these compounds belong to the terpene and polyphenol classes. While it is known that they do not necessarily act directly on the cannabinoid receptors CB1 and CB2, their ability to regulate their expression levels has already been shown in some disease-related models, as well as their ability to modulate the activity of other components of the system. In this review, evidence was gathered to support the idea that phytocannabinoid dietary intake may indeed be a viable strategy for disease prevention and may be helpful in maintaining the health status. In an era where personalized nutrition is becoming more and more a reality, having new therapeutic targets could become an important resource.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu14030468