Evaluation of Ferroptosis-related Gene AKR1C1 as a Novel Biomarker Associated with the Immune Microenvironment and Prognosis in Breast Cancer

Ferroptosis is the latest-discovered, iron-dependent form of regulated cell death. It has been increasingly recognized that ferroptosis-related genes participate in oncogenesis and development of cancers, including breast cancer ( ). Thus, It is important to explore the biofunctions of ferroptosis-r...

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Bibliographic Details
Published in:International journal of general medicine 2021-01, Vol.14, p.6189-6200
Main Authors: Zhang, Zeyu, Qiu, Xiangyuan, Yan, Yuanliang, Liang, Qiujiu, Cai, Yuan, Peng, Bi, Xu, Zhijie, Xia, Fada
Format: Article
Language:English
Subjects:
akr1c1
Analysis
B cells
Breast cancer
Cancer
Cell death
Correlation analysis
Dendritic cells
Development and progression
Fanconi's anemia
Ferroptosis
Gene expression
Genes
Genetic aspects
Genetic transcription
immune infiltration
immune microenvironment
Immunology
Medical prognosis
Ontology
Original Research
Patients
Prognosis
Regression analysis
Skin cancer
Survival analysis
Variance analysis
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Summary:Ferroptosis is the latest-discovered, iron-dependent form of regulated cell death. It has been increasingly recognized that ferroptosis-related genes participate in oncogenesis and development of cancers, including breast cancer ( ). Thus, It is important to explore the biofunctions of ferroptosis-related genes in . Transcriptome microarray datasets (GSE22358, GSE9014 and GSE8977, GSE2990 and GSE2034) and TCGA- were retrieved for analyses. And a variety of computational tools were used to identify the roles and associated biological functions in . Two ferroptosis-related genes ( and ) were significantly expressed in GSE22358, GSE9014 and GSE8977. Higher expression of was related with favorable prognosis. TCGA- further confirmed the expression of and the prognostic value of . Co-expression analyses showed the most enriched GO term and KEGG pathways were termination of DNA-templated transcription and Fanconi anemia pathway. Subsequently, immunological analyses showed was significantly associated with various immune infiltration cells; among these, dendritic cells, neutrophils, macrophages were the top three infiltrating cells. Furthermore, was also associated with multiple immunostimulatory molecules and chemokines, including PD-1, PD-L1, CTLA4, B7-H3, VSIR, IL-6, BTLA, CXCL2, and CCR7. These results indicated the potential roles of in the immune reaction during the pathogenesis of breast cancer. This study firstly demonstrated that ferroptosis-related gene, , could be associated with immune microenvironment, thereby influencing the development and prognosis of patient with breast cancer.
ISSN:1178-7074
1178-7074
DOI:10.2147/IJGM.S329031