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Evaluation of Ferroptosis-related Gene AKR1C1 as a Novel Biomarker Associated with the Immune Microenvironment and Prognosis in Breast Cancer
Ferroptosis is the latest-discovered, iron-dependent form of regulated cell death. It has been increasingly recognized that ferroptosis-related genes participate in oncogenesis and development of cancers, including breast cancer ( ). Thus, It is important to explore the biofunctions of ferroptosis-r...
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| Published in: | International journal of general medicine 2021-01, Vol.14, p.6189-6200 |
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| container_title | International journal of general medicine |
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| creator | Zhang, Zeyu Qiu, Xiangyuan Yan, Yuanliang Liang, Qiujiu Cai, Yuan Peng, Bi Xu, Zhijie Xia, Fada |
| description | Ferroptosis is the latest-discovered, iron-dependent form of regulated cell death. It has been increasingly recognized that ferroptosis-related genes participate in oncogenesis and development of cancers, including breast cancer (
). Thus, It is important to explore the biofunctions of ferroptosis-related genes in
.
Transcriptome microarray datasets (GSE22358, GSE9014 and GSE8977, GSE2990 and GSE2034) and TCGA-
were retrieved for analyses. And a variety of computational tools were used to identify the roles and associated biological functions in
.
Two ferroptosis-related genes (
and
) were significantly expressed in GSE22358, GSE9014 and GSE8977. Higher expression of
was related with favorable prognosis. TCGA-
further confirmed the expression of
and the prognostic value of
. Co-expression analyses showed the most enriched GO term and KEGG pathways were termination of DNA-templated transcription and Fanconi anemia pathway. Subsequently, immunological analyses showed
was significantly associated with various immune infiltration cells; among these, dendritic cells, neutrophils, macrophages were the top three infiltrating cells. Furthermore,
was also associated with multiple immunostimulatory molecules and chemokines, including PD-1, PD-L1, CTLA4, B7-H3, VSIR, IL-6, BTLA, CXCL2, and CCR7. These results indicated the potential roles of
in the immune reaction during the pathogenesis of breast cancer.
This study firstly demonstrated that ferroptosis-related gene,
, could be associated with immune microenvironment, thereby influencing the development and prognosis of patient with breast cancer. |
| doi_str_mv | 10.2147/IJGM.S329031 |
| format | article |
| fullrecord | <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_98e634e9db96475790cf02c313706c9d</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A679837956</galeid><doaj_id>oai_doaj_org_article_98e634e9db96475790cf02c313706c9d</doaj_id><sourcerecordid>A679837956</sourcerecordid><originalsourceid>FETCH-LOGICAL-c576t-a2c2cd46567013c283286d381093ea71da13ad22585a4ca9232dabc8331df9f03</originalsourceid><addsrcrecordid>eNptkktvEzEUhUcIREthxxpZQkIsSPBjxh5vKqVRWwItIB5ry7HvJA4zdrFngvgR_GecJpQEIS9s2d89V-f6FMVTgseUlOL17O3l9fgzoxIzcq84JkTUI4FFeX_vfFQ8SmmFMeecsIfFESs5ISWjx8Wv87VuB9274FFo0AXEGG76kFwaRWh1DxZdggc0efeJTAnSCWn0PqyhRWcudDp-g4gmKQXjbtkfrl-ifglo1nVDLrt2JgbwaxeD78D3SHuLPsaw8JsWyHl0FkGnHk21NxAfFw8a3SZ4sttPiq8X51-mb0ZXHy5n08nVyFSC9yNNDTW25BUXmDBDa0ZrbllNsGSgBbGaMG0prepKl0ZLyqjVc1MzRmwjG8xOitlW1wa9UjfRZSc_VdBO3V6EuFA69s60oGQNnJUg7VzyUlRCYtNgahhhAnMjbdY63WrdDPMOrMkuo24PRA9fvFuqRViruqwFlWUWeLkTiOH7AKlXnUsG2lZ7CENSNDflVGY3GX3-D7oKQ_R5VJmqaSk549VfaqGzAeebkPuajaiacCFrJmTFMzX-D5WXhc6Z4KFx-f6g4MVewRJ02y9TaIdNdtIh-GoL5r9PKUJzNwyC1SazapNZtctsxp_tD_AO_hNS9hs1HuUM</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2582496365</pqid></control><display><type>article</type><title>Evaluation of Ferroptosis-related Gene AKR1C1 as a Novel Biomarker Associated with the Immune Microenvironment and Prognosis in Breast Cancer</title><source>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</source><source>Taylor & Francis Open Access</source><source>PubMed Central</source><creator>Zhang, Zeyu ; Qiu, Xiangyuan ; Yan, Yuanliang ; Liang, Qiujiu ; Cai, Yuan ; Peng, Bi ; Xu, Zhijie ; Xia, Fada</creator><creatorcontrib>Zhang, Zeyu ; Qiu, Xiangyuan ; Yan, Yuanliang ; Liang, Qiujiu ; Cai, Yuan ; Peng, Bi ; Xu, Zhijie ; Xia, Fada</creatorcontrib><description>Ferroptosis is the latest-discovered, iron-dependent form of regulated cell death. It has been increasingly recognized that ferroptosis-related genes participate in oncogenesis and development of cancers, including breast cancer (
). Thus, It is important to explore the biofunctions of ferroptosis-related genes in
.
Transcriptome microarray datasets (GSE22358, GSE9014 and GSE8977, GSE2990 and GSE2034) and TCGA-
were retrieved for analyses. And a variety of computational tools were used to identify the roles and associated biological functions in
.
Two ferroptosis-related genes (
and
) were significantly expressed in GSE22358, GSE9014 and GSE8977. Higher expression of
was related with favorable prognosis. TCGA-
further confirmed the expression of
and the prognostic value of
. Co-expression analyses showed the most enriched GO term and KEGG pathways were termination of DNA-templated transcription and Fanconi anemia pathway. Subsequently, immunological analyses showed
was significantly associated with various immune infiltration cells; among these, dendritic cells, neutrophils, macrophages were the top three infiltrating cells. Furthermore,
was also associated with multiple immunostimulatory molecules and chemokines, including PD-1, PD-L1, CTLA4, B7-H3, VSIR, IL-6, BTLA, CXCL2, and CCR7. These results indicated the potential roles of
in the immune reaction during the pathogenesis of breast cancer.
This study firstly demonstrated that ferroptosis-related gene,
, could be associated with immune microenvironment, thereby influencing the development and prognosis of patient with breast cancer.</description><identifier>ISSN: 1178-7074</identifier><identifier>EISSN: 1178-7074</identifier><identifier>DOI: 10.2147/IJGM.S329031</identifier><identifier>PMID: 34611432</identifier><language>eng</language><publisher>New Zealand: Dove Medical Press Limited</publisher><subject>akr1c1 ; Analysis ; B cells ; Breast cancer ; Cancer ; Cell death ; Correlation analysis ; Dendritic cells ; Development and progression ; Fanconi's anemia ; Ferroptosis ; Gene expression ; Genes ; Genetic aspects ; Genetic transcription ; immune infiltration ; immune microenvironment ; Immunology ; Medical prognosis ; Ontology ; Original Research ; Patients ; Prognosis ; Regression analysis ; Skin cancer ; Survival analysis ; Variance analysis</subject><ispartof>International journal of general medicine, 2021-01, Vol.14, p.6189-6200</ispartof><rights>2021 Zhang et al.</rights><rights>COPYRIGHT 2021 Dove Medical Press Limited</rights><rights>2021. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 Zhang et al. 2021 Zhang et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c576t-a2c2cd46567013c283286d381093ea71da13ad22585a4ca9232dabc8331df9f03</citedby><cites>FETCH-LOGICAL-c576t-a2c2cd46567013c283286d381093ea71da13ad22585a4ca9232dabc8331df9f03</cites><orcidid>0000-0003-2047-883X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2582496365/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2582496365?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34611432$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Zeyu</creatorcontrib><creatorcontrib>Qiu, Xiangyuan</creatorcontrib><creatorcontrib>Yan, Yuanliang</creatorcontrib><creatorcontrib>Liang, Qiujiu</creatorcontrib><creatorcontrib>Cai, Yuan</creatorcontrib><creatorcontrib>Peng, Bi</creatorcontrib><creatorcontrib>Xu, Zhijie</creatorcontrib><creatorcontrib>Xia, Fada</creatorcontrib><title>Evaluation of Ferroptosis-related Gene AKR1C1 as a Novel Biomarker Associated with the Immune Microenvironment and Prognosis in Breast Cancer</title><title>International journal of general medicine</title><addtitle>Int J Gen Med</addtitle><description>Ferroptosis is the latest-discovered, iron-dependent form of regulated cell death. It has been increasingly recognized that ferroptosis-related genes participate in oncogenesis and development of cancers, including breast cancer (
). Thus, It is important to explore the biofunctions of ferroptosis-related genes in
.
Transcriptome microarray datasets (GSE22358, GSE9014 and GSE8977, GSE2990 and GSE2034) and TCGA-
were retrieved for analyses. And a variety of computational tools were used to identify the roles and associated biological functions in
.
Two ferroptosis-related genes (
and
) were significantly expressed in GSE22358, GSE9014 and GSE8977. Higher expression of
was related with favorable prognosis. TCGA-
further confirmed the expression of
and the prognostic value of
. Co-expression analyses showed the most enriched GO term and KEGG pathways were termination of DNA-templated transcription and Fanconi anemia pathway. Subsequently, immunological analyses showed
was significantly associated with various immune infiltration cells; among these, dendritic cells, neutrophils, macrophages were the top three infiltrating cells. Furthermore,
was also associated with multiple immunostimulatory molecules and chemokines, including PD-1, PD-L1, CTLA4, B7-H3, VSIR, IL-6, BTLA, CXCL2, and CCR7. These results indicated the potential roles of
in the immune reaction during the pathogenesis of breast cancer.
This study firstly demonstrated that ferroptosis-related gene,
, could be associated with immune microenvironment, thereby influencing the development and prognosis of patient with breast cancer.</description><subject>akr1c1</subject><subject>Analysis</subject><subject>B cells</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Cell death</subject><subject>Correlation analysis</subject><subject>Dendritic cells</subject><subject>Development and progression</subject><subject>Fanconi's anemia</subject><subject>Ferroptosis</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic transcription</subject><subject>immune infiltration</subject><subject>immune microenvironment</subject><subject>Immunology</subject><subject>Medical prognosis</subject><subject>Ontology</subject><subject>Original Research</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Regression analysis</subject><subject>Skin cancer</subject><subject>Survival analysis</subject><subject>Variance analysis</subject><issn>1178-7074</issn><issn>1178-7074</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkktvEzEUhUcIREthxxpZQkIsSPBjxh5vKqVRWwItIB5ry7HvJA4zdrFngvgR_GecJpQEIS9s2d89V-f6FMVTgseUlOL17O3l9fgzoxIzcq84JkTUI4FFeX_vfFQ8SmmFMeecsIfFESs5ISWjx8Wv87VuB9274FFo0AXEGG76kFwaRWh1DxZdggc0efeJTAnSCWn0PqyhRWcudDp-g4gmKQXjbtkfrl-ifglo1nVDLrt2JgbwaxeD78D3SHuLPsaw8JsWyHl0FkGnHk21NxAfFw8a3SZ4sttPiq8X51-mb0ZXHy5n08nVyFSC9yNNDTW25BUXmDBDa0ZrbllNsGSgBbGaMG0prepKl0ZLyqjVc1MzRmwjG8xOitlW1wa9UjfRZSc_VdBO3V6EuFA69s60oGQNnJUg7VzyUlRCYtNgahhhAnMjbdY63WrdDPMOrMkuo24PRA9fvFuqRViruqwFlWUWeLkTiOH7AKlXnUsG2lZ7CENSNDflVGY3GX3-D7oKQ_R5VJmqaSk549VfaqGzAeebkPuajaiacCFrJmTFMzX-D5WXhc6Z4KFx-f6g4MVewRJ02y9TaIdNdtIh-GoL5r9PKUJzNwyC1SazapNZtctsxp_tD_AO_hNS9hs1HuUM</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Zhang, Zeyu</creator><creator>Qiu, Xiangyuan</creator><creator>Yan, Yuanliang</creator><creator>Liang, Qiujiu</creator><creator>Cai, Yuan</creator><creator>Peng, Bi</creator><creator>Xu, Zhijie</creator><creator>Xia, Fada</creator><general>Dove Medical Press Limited</general><general>Taylor & Francis Ltd</general><general>Dove</general><general>Dove Medical Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-2047-883X</orcidid></search><sort><creationdate>20210101</creationdate><title>Evaluation of Ferroptosis-related Gene AKR1C1 as a Novel Biomarker Associated with the Immune Microenvironment and Prognosis in Breast Cancer</title><author>Zhang, Zeyu ; Qiu, Xiangyuan ; Yan, Yuanliang ; Liang, Qiujiu ; Cai, Yuan ; Peng, Bi ; Xu, Zhijie ; Xia, Fada</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c576t-a2c2cd46567013c283286d381093ea71da13ad22585a4ca9232dabc8331df9f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>akr1c1</topic><topic>Analysis</topic><topic>B cells</topic><topic>Breast cancer</topic><topic>Cancer</topic><topic>Cell death</topic><topic>Correlation analysis</topic><topic>Dendritic cells</topic><topic>Development and progression</topic><topic>Fanconi's anemia</topic><topic>Ferroptosis</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic transcription</topic><topic>immune infiltration</topic><topic>immune microenvironment</topic><topic>Immunology</topic><topic>Medical prognosis</topic><topic>Ontology</topic><topic>Original Research</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Regression analysis</topic><topic>Skin cancer</topic><topic>Survival analysis</topic><topic>Variance analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Zeyu</creatorcontrib><creatorcontrib>Qiu, Xiangyuan</creatorcontrib><creatorcontrib>Yan, Yuanliang</creatorcontrib><creatorcontrib>Liang, Qiujiu</creatorcontrib><creatorcontrib>Cai, Yuan</creatorcontrib><creatorcontrib>Peng, Bi</creatorcontrib><creatorcontrib>Xu, Zhijie</creatorcontrib><creatorcontrib>Xia, Fada</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest research library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>International journal of general medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Zeyu</au><au>Qiu, Xiangyuan</au><au>Yan, Yuanliang</au><au>Liang, Qiujiu</au><au>Cai, Yuan</au><au>Peng, Bi</au><au>Xu, Zhijie</au><au>Xia, Fada</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of Ferroptosis-related Gene AKR1C1 as a Novel Biomarker Associated with the Immune Microenvironment and Prognosis in Breast Cancer</atitle><jtitle>International journal of general medicine</jtitle><addtitle>Int J Gen Med</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>14</volume><spage>6189</spage><epage>6200</epage><pages>6189-6200</pages><issn>1178-7074</issn><eissn>1178-7074</eissn><abstract>Ferroptosis is the latest-discovered, iron-dependent form of regulated cell death. It has been increasingly recognized that ferroptosis-related genes participate in oncogenesis and development of cancers, including breast cancer (
). Thus, It is important to explore the biofunctions of ferroptosis-related genes in
.
Transcriptome microarray datasets (GSE22358, GSE9014 and GSE8977, GSE2990 and GSE2034) and TCGA-
were retrieved for analyses. And a variety of computational tools were used to identify the roles and associated biological functions in
.
Two ferroptosis-related genes (
and
) were significantly expressed in GSE22358, GSE9014 and GSE8977. Higher expression of
was related with favorable prognosis. TCGA-
further confirmed the expression of
and the prognostic value of
. Co-expression analyses showed the most enriched GO term and KEGG pathways were termination of DNA-templated transcription and Fanconi anemia pathway. Subsequently, immunological analyses showed
was significantly associated with various immune infiltration cells; among these, dendritic cells, neutrophils, macrophages were the top three infiltrating cells. Furthermore,
was also associated with multiple immunostimulatory molecules and chemokines, including PD-1, PD-L1, CTLA4, B7-H3, VSIR, IL-6, BTLA, CXCL2, and CCR7. These results indicated the potential roles of
in the immune reaction during the pathogenesis of breast cancer.
This study firstly demonstrated that ferroptosis-related gene,
, could be associated with immune microenvironment, thereby influencing the development and prognosis of patient with breast cancer.</abstract><cop>New Zealand</cop><pub>Dove Medical Press Limited</pub><pmid>34611432</pmid><doi>10.2147/IJGM.S329031</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-2047-883X</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of general medicine, 2021-01, Vol.14, p.6189-6200 |
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| language | eng |
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| subjects | akr1c1 Analysis B cells Breast cancer Cancer Cell death Correlation analysis Dendritic cells Development and progression Fanconi's anemia Ferroptosis Gene expression Genes Genetic aspects Genetic transcription immune infiltration immune microenvironment Immunology Medical prognosis Ontology Original Research Patients Prognosis Regression analysis Skin cancer Survival analysis Variance analysis |
| title | Evaluation of Ferroptosis-related Gene AKR1C1 as a Novel Biomarker Associated with the Immune Microenvironment and Prognosis in Breast Cancer |
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