S. boulardii Early Intervention Maintains Gut Microbiome Structure and Promotes Gut Mucosal Barrier Function in Early-Weaned Rats

Early weaning leads to the disorder of the gut microbiome and gut mucosal barrier injury. Early intervention of gut microbiome colonization contributes to the development of the gut microbiome and gut function. The aim of this study was to explore the effects of Saccharomyces boulardii (S. boulardii...

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Bibliographic Details
Published in:Nutrients 2022-08, Vol.14 (17), p.3485
Main Authors: Yang, Zhipeng, Wu, Yanting, Liu, Xiangchen, Zhang, Mei, Peng, Jian, Wei, Hongkui
Format: Article
Language:English
Subjects:
Bacteria
Colonization
Digestive system
Drinking water
Early intervention
early-weaned rats
Gene expression
Goblet cells
gut microbiome homeostasis
gut mucosal barrier
Homeostasis
Inflammation
Inflammatory response
inflammatory responses
Intervention
Intestinal microflora
Laboratory animals
Medical research
Metabolism
microbial metabolism
Microbiomes
Microbiota
Microorganisms
Mucosa
Proteins
Reagents
Saccharomyces boulardii
Taxonomy
Weaning
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Summary:Early weaning leads to the disorder of the gut microbiome and gut mucosal barrier injury. Early intervention of gut microbiome colonization contributes to the development of the gut microbiome and gut function. The aim of this study was to explore the effects of Saccharomyces boulardii (S. boulardii) early intervention on the gut microbiome structure and gut mucosal barrier function of early-weaned rats. The results showed that S. boulardii early intervention improved growth performance along with a decrease in pathogenic bacteria, an increase in beneficial bacteria, a stable and complex microbiome, and a high level of microbial metabolism. Moreover, S. boulardii upregulated the mucosal barrier function including goblet cells and relative gene expression, tight junction, and sIgA level. Furthermore, S. boulardii suppressed the inflammatory response and promoted the anti-inflammatory response. Our study may provide a possible early intervention strategy for preventing an early weaning-induced disorder of the gut microbiome and loss of gut mucosal barrier function.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu14173485