Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge

Many milestones in medical history rest on animal modeling of human diseases. The SARS-CoV-2 pandemic has evoked a tremendous investigative effort primarily centered on clinical studies. However, several animal SARS-CoV-2/COVID-19 models have been developed and pre-clinical findings aimed at support...

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Bibliographic Details
Published in:EBioMedicine 2021-04, Vol.66, p.103291-103291, Article 103291
Main Authors: Winkler, Martin S., Skirecki, Tomasz, Brunkhorst, Frank M., Cajander, Sara, Cavaillon, Jean-Marc, Ferrer, Ricard, Flohé, Stefanie B., García-Salido, Alberto, Giamarellos-Bourboulis, Evangelos J., Girardis, Massimo, Kox, Matthijs, Lachmann, Gunnar, Martin-Loeches, Ignacio, Netea, Mihai G., Spinetti, Thibaud, Schefold, Joerg C., Torres, Antoni, Uhle, Florian, Venet, Fabienne, Weis, Sebastian, Scherag, André, Rubio, Ignacio, Osuchowski, Marcin F.
Format: Article
Language:English
Subjects:
Age Factors
Animal model
Animals
Antiviral Agents - pharmacology
Clinical trial
Clinical Trials as Topic
COVID-19
COVID-19 - drug therapy
COVID-19 - etiology
COVID-19 - physiopathology
COVID-19 - therapy
COVID-19 Vaccines - pharmacology
Cricetinae
Disease Models, Animal
Ferrets
Humans
Life Sciences
Mice
Mutation
Pandemic
Pre-clinical research
Primates
Review
SARS-CoV-2 - genetics
Vaccine
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Summary:Many milestones in medical history rest on animal modeling of human diseases. The SARS-CoV-2 pandemic has evoked a tremendous investigative effort primarily centered on clinical studies. However, several animal SARS-CoV-2/COVID-19 models have been developed and pre-clinical findings aimed at supporting clinical evidence rapidly emerge. In this review, we characterize the existing animal models exposing their relevance and limitations as well as outline their utility in COVID-19 drug and vaccine development. Concurrently, we summarize the status of clinical trial research and discuss the novel tactics utilized in the largest multi-center trials aiming to accelerate generation of reliable results that may subsequently shape COVID-19 clinical treatment practices. We also highlight areas of improvement for animal studies in order to elevate their translational utility. In pandemics, to optimize the use of strained resources in a short time-frame, optimizing and strengthening the synergy between the preclinical and clinical domains is pivotal.
ISSN:2352-3964
2352-3964
DOI:10.1016/j.ebiom.2021.103291