Some variables affecting the characteristics of Eudragit E-sodium alginate polyelectrolyte complex as a tablet matrix for diltiazem hydrochloride

Eudragit E (EE)-sodium alginate (SA) polyelectrolyte complexes (PECs) were prepared at pH 4 and 5.8 using sodium alginate of high (SAH) and low viscosity (SAL). The optimum EE-SA complexation mass ratio was determined using viscosity measurements. Interactions between EE and SA in PECs were characte...

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Bibliographic Details
Published in:Acta Pharmaceutica 2014-03, Vol.64 (1), p.89-104
Main Authors: Yusif, Rehab Mohammad, Hashim, Irhan Ibrahim Abu, El-Dahan, Marwa Salah
Format: Article
Language:English
Subjects:
Alginates - chemistry
Diltiazem - chemistry
diltiazem hydrochloride
Drug Carriers - chemistry
Eudragit E 100
Glucuronic Acid - chemistry
Hexuronic Acids - chemistry
Methylmethacrylates - chemistry
polyelectrolyte complex
sodium alginate
Spectroscopy, Fourier Transform Infrared - methods
tablet matrix
viscosity
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Summary:Eudragit E (EE)-sodium alginate (SA) polyelectrolyte complexes (PECs) were prepared at pH 4 and 5.8 using sodium alginate of high (SAH) and low viscosity (SAL). The optimum EE-SA complexation mass ratio was determined using viscosity measurements. Interactions between EE and SA in PECs were characterized by Fourier transform infra-red spectroscopy (FT-IR) and differential scanning calorimetry (DSC). Diltiazem hydrochloride (DTZ HCl) tablets were prepared using the prepared EE-SA PECs and their physical mixtures at different ratios as matrices. Tablets were evaluated for swelling characteristics and in vitro drug release. Tablets containing EE-SAH physical mixtures of ratios (1.5:1 and 1:3) as matrices were effective in achieving sustained release of DTZ HCl, where the percent drug released was significantly (p < 0.05) decreased compared to that from tablets either containing the same ratios of EE-SAL physical mixtures or the preformed EE- -SAH and EE-SAL PECs.
ISSN:1330-0075
1846-9558
DOI:10.2478/acph-2014-0010