Fatal VAP-related pulmonary aspergillosis by Aspergillus niger in a positive COVID-19 patient

Invasive pulmonary aspergillosis, known as a complication in patients with severe respiratory syndromes, recently showed a correlation with COVID-19 pneumonia, and the clinical characteristics of COVID-19 associated pulmonary aspergillosis (CAPA) have been described. Unfortunately, infections by the...

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Bibliographic Details
Published in:Respiratory medicine case reports 2021-01, Vol.32, p.101367, Article 101367
Main Authors: Trovato, Laura, Calvo, Maddalena, Migliorisi, Giuseppe, Astuto, Marinella, Oliveri, Francesco, Oliveri, Salvatore
Format: Article
Language:English
Subjects:
Aspergillus niger
Case Report
Coinfection
Pulmonary aspergillosis
SARS-CoV-2
Ventilator-associated pneumonia
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Summary:Invasive pulmonary aspergillosis, known as a complication in patients with severe respiratory syndromes, recently showed a correlation with COVID-19 pneumonia, and the clinical characteristics of COVID-19 associated pulmonary aspergillosis (CAPA) have been described. Unfortunately, infections by the Aspergillus genus are often diagnosed in post-mortem time, because of diagnostic delays and a rapid worsening of respiratory conditions. Literature data document, in fact, only few cases of COVID-19 Aspergillus niger coinfection. The aim of this study was to describe a case of a VAP-related probable pulmonary aspergillosis by Aspergillus niger in a COVID-19 patient. Despite the definition of fungal etiology and the rapid administration of antifungal therapy, the patient died while on ventilator support because of severe respiratory impairment.
ISSN:2213-0071
2213-0071
DOI:10.1016/j.rmcr.2021.101367