Genomic Epidemiology of Vibrio cholerae O139, Zhejiang Province, China, 1994-2018

Cholera caused by Vibrio cholerae O139 was first reported in Bangladesh and India in 1992. To determine the genomic epidemiology and origins of O139 in China, we sequenced 104 O139 isolates collected from Zhejiang Province, China, during 1994-2018 and compared them with 57 O139 genomes from other co...

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Bibliographic Details
Published in:Emerging infectious diseases 2022-11, Vol.28 (11), p.2253-2260
Main Authors: Luo, Yun, Ye, Julian, Payne, Michael, Hu, Dalong, Jiang, Jianmin, Lan, Ruiting
Format: Article
Language:English
Subjects:
Analysis
Anti-infective agents
Antigens
Antimicrobial agents
Archives & records
Care and treatment
China - epidemiology
Cholera
Cholera - epidemiology
Cholera toxin
Chromosomes
Cloning
Control
Diagnosis
Dosage and administration
Drug resistance in microorganisms
Epidemics
Epidemiology
Fluid therapy
Genes
Genomes
genomic
Genomic Epidemiology of
Genomics
Humans
Identification and classification
Metadata
Nucleotides
O139
Pandemics
Patient outcomes
Phylogenetics
Plasmids
Prevention
Quinolones
Single nucleotide polymorphisms
Thailand - epidemiology
Vibrio cholerae
Vibrio cholerae O1
Vibrio cholerae O139 - genetics
Virulence
Waterborne diseases
Zhejiang
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Summary:Cholera caused by Vibrio cholerae O139 was first reported in Bangladesh and India in 1992. To determine the genomic epidemiology and origins of O139 in China, we sequenced 104 O139 isolates collected from Zhejiang Province, China, during 1994-2018 and compared them with 57 O139 genomes from other countries in Asia. Most Zhejiang isolates fell into 3 clusters (C1-C3), which probably originated in India (C1) and Thailand (C2 and C3) during the early 1990s. Different clusters harbored different antimicrobial resistance genes and IncA/C plasmids. The integrative and conjugative elements carried by Zhejiang isolates were of a new type, differing from ICEVchInd4 and SXT by single-nucleotide polymorphisms and presence of genes. Quinolone resistance-conferring mutations S85L in parC and S83I in gyrA occurred in 71.2% of the Zhejiang isolates. The ctxB copy number differed among the 3 clusters. Our findings provided new insights for prevention and control of O139 cholera .
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2811.212066