The Analysis of Dynamic Changes and Prognosis of Posner–Schlossman Syndrome with Cytomegalovirus Infection and Antiviral Therapy

Purpose. To analyze how keratic precipitate (KP) morphology changes during Posner–Schlossman syndrome (PSS) prognosis and raise medication suggestions on 2% ganciclovir eye drops. Materials and Methods. Clinical retrospective cohort study in the Eye & ENT Hospital of Fudan University, Shanghai,...

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Bibliographic Details
Published in:Journal of ophthalmology 2021, Vol.2021, p.6687929-6
Main Authors: Sheng, Qilian, Zhai, Ruyi, Fan, Xintong, Kong, Xiangmei
Format: Article
Language:English
Subjects:
Analysis
Antibodies
Clinical medicine
Cornea
Cytomegalovirus
Cytomegalovirus infections
Ganciclovir
Glaucoma
Health aspects
Hospitals
Immunoglobulin G
Infections
Inflammation
Medical prognosis
Morphology
Pathogenesis
Prognosis
Standard deviation
Statistical analysis
Steroids
Survival analysis
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Summary:Purpose. To analyze how keratic precipitate (KP) morphology changes during Posner–Schlossman syndrome (PSS) prognosis and raise medication suggestions on 2% ganciclovir eye drops. Materials and Methods. Clinical retrospective cohort study in the Eye & ENT Hospital of Fudan University, Shanghai, China. The attacked eyes of 98 eligible subjects diagnosed unilateral PSS were enrolled between 2016 and 2019. All patients were treated with intraocular pressure-lowering drugs and anti-inflammatory steroids. 2% ganciclovir eye drops were given to cytomegalovirus (CMV) immunoglobulin G (IgG) correction ratio positive patients. Frequent follow-ups and examinations were performed. KP morphology was focused and categorized into coin-shaped, mutton-fat, and pigmented. Medical histories were noted. Multidimensional analysis was given. Results. Totally 47 patients in 98 achieved all-KP disappearance. Mean treatment time was (5.13 ± 3.66) weeks. Total KP disappearance was negatively correlated with mutton-fat and pigmented KPs at the first visit (P=0.020, P=0.007) and treatment time was also longer (P=0.018, P=0.014). Mean cumulative steroids dosage for 47 subjects was (159.66 ± 161.84) drops. CMV IgG correction ratio positive patients had smaller corneal endothelial cell density (P
ISSN:2090-004X
2090-0058
DOI:10.1155/2021/6687929