Imbalance of Peripheral Th17 and Regulatory T Cells in Children with Allergic Rhinitis and Bronchial Asthma

The purpose of the present study is to investigate the prevalence of Th17 and regulatory T (Treg) cells in children with allergic rhinitis (AR) accompanying with bronchial asthma (BA). 24 children with AR, 22 children with BA, 18 children with AR accompanying with BA, and 20 healthy controls were re...

Full description

Saved in:
Bibliographic Details
Published in:Iranian journal of allergy, asthma, and immunology asthma, and immunology, 2015-06, Vol.14 (3), p.273-273
Main Authors: Tao, Baohong, Ruan, Guiying, Wang, Dongguo, Li, Yong, Wang, Zhuping, Yin, Genquan
Format: Article
Language:English
Subjects:
Adolescent
Allergic Rhinitis
Allergies
Asthma
Asthma - immunology
Bronchial Asthma
Child
Cytokines
Cytokines - blood
Disease
Female
Humans
Lymphocytes
Male
Pathogenesis
Rhinitis, Allergic - immunology
Statistical analysis
Studies
T-Lymphocytes, Regulatory - immunology
Th17 cells
Th17 Cells - immunology
Treg cells
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The purpose of the present study is to investigate the prevalence of Th17 and regulatory T (Treg) cells in children with allergic rhinitis (AR) accompanying with bronchial asthma (BA). 24 children with AR, 22 children with BA, 18 children with AR accompanying with BA, and 20 healthy controls were recruited. The prevalence of peripheral blood Th17 and Treg cells were determined by flow cytometry. mRNA expression of retinoid-acid receptor-related orphan receptor (ROR)-γt and forkhead box P3 (Foxp3) were determined by realtime polymerase chain reaction. Cytokine expressions in plasma were determined by enzyme linked immunosorbent assay. The frequency of Th17 cells, ROR-γt mRNA expression, and the plasma levels of IL-17 were significantly higher, while Treg cells and Transforming growth factor (TGF)-β1 were significantly lower in children with AR accompanying with BA compared with those in children with AR or BA alone or control subjects. In children with allergic airway disease, total IgE levels were positively correlated to the frequency of Th17 cells (r=0.607, p
ISSN:1735-1502
1735-5249