11C-PIB PET imaging reveals that amyloid deposition in cases with early-onset Alzheimer’s disease in the absence of known mutations retains higher levels of PIB in the basal ganglia

Purpose: Early-onset Alzheimer’s disease (EOAD) has a different pathologic burden and clinical features compared with late-onset Alzheimer’s disease (LOAD). We examined the effects of age at onset on the burden and distribution of β-amyloid in patients with EOAD, in whom well-characterized mutations...

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Published in:Clinical interventions in aging 2017-01, Vol.12, p.1041-1048
Main Authors: Youn, Young Chul, Jae-Won Jang, Su-Hyun, Han, Kim, HyeRyoun, Ju-Won, Seok, Byun, Jun Soo, Park, Kwang-Yeol, An, Seong Soo A, In Kook Chun, Kim, SangYun
Format: Article
Language:English
Subjects:
Age
Alzheimer disease early-onset Alzheimer disease amyloid PET
Alzheimer's disease
Brain
Dementia
Demographics
Laboratories
Medical imaging
Mutation
Neurology
NMR
Nuclear magnetic resonance
Nuclear medicine
Original Research
Patients
Retention
University colleges
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Summary:Purpose: Early-onset Alzheimer’s disease (EOAD) has a different pathologic burden and clinical features compared with late-onset Alzheimer’s disease (LOAD). We examined the effects of age at onset on the burden and distribution of β-amyloid in patients with EOAD, in whom well-characterized mutations associated with Alzheimer’s disease were absent. Methods: We genotypedApoE, APP, PSEN1 and PSEN2 in the patients with Alzheimer’s disease: 9 patients with EOAD (age 70) and 8 normal controls (NCs), all of whom had undergone 11C-labeled Pittsburgh compound B-positron emission tomography imaging. Results: Patients with EOAD exhibited higherz scores and larger cluster sizes, and retained higher levels of Pittsburgh compound B in the bilateral thalamus and in some parts of the globus pallidus (P
ISSN:1176-9092
1178-1998
1178-1998
DOI:10.2147/CIA.S132884