SARS-CoV-2 Infection and Pancreatic β Cell Failure

SARS-CoV-2 infection primarily causes pulmonary symptoms; however, accumulating reports indicate that some patients with COVID-19 have multiple organ dysfunction or failure. Although diabetes is considered a risk factor for severe COVID-19, SARS-CoV-2 infection may also be a causal factor for diabet...

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Bibliographic Details
Published in:Biology (Basel, Switzerland) Switzerland), 2021-12, Vol.11 (1), p.22
Main Authors: Mine, Keiichiro, Nagafuchi, Seiho, Mori, Hitoe, Takahashi, Hirokazu, Anzai, Keizo
Format: Article
Language:English
Subjects:
Beta cells
Coronaviruses
COVID-19
diabetes
Diabetes mellitus
Insulin resistance
Middle East respiratory syndrome
Pancreas
Review
Risk factors
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Viral infections
virus
Viruses
β cell
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Summary:SARS-CoV-2 infection primarily causes pulmonary symptoms; however, accumulating reports indicate that some patients with COVID-19 have multiple organ dysfunction or failure. Although diabetes is considered a risk factor for severe COVID-19, SARS-CoV-2 infection may also be a causal factor for diabetes mellitus in patients with COVID-19. According to the research reviewed in this paper, the pancreas and pancreatic β cells appear to be targets of SARS-CoV-2 and are damaged by direct or indirect effects of the infection. However, controversial results have been reported between study groups, mainly due to the limited number of cases with diabetes precipitated by COVID-19. In this review, we comprehensively discuss the published findings on the potential association between SARS-CoV-2 infection or COVID-19 and pancreatic β-cell damage leading to diabetes onset. These findings will further contribute to our understanding of the pathogenesis of diabetes mellitus.
ISSN:2079-7737
2079-7737
DOI:10.3390/biology11010022