Microwave assisted synthesis of some new coumarin-pyrazoline hybrids and their antimicrobial activity

A series of pyrazolines were synthesized by Michael addition of chalcones with hydrazine hydrate in the presence of sodium acetate under conventional heating and microwave irradiation. The structures of the newly synthesized chalcones and pyrazolines were established based on IR, 1H- and 13C-NMR and...

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Bibliographic Details
Published in:Journal of the Serbian Chemical Society 2015-01, Vol.80 (3), p.305-313
Main Authors: Ashok, Dongamanti, Lakshmi, Bommidi, Ravi, Sidda, Ganesh, Arram
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Antimicrobial agents
Bacteria
chalcones
Coumarin
Michael addition
microwave irradiation
NMR
Nuclear magnetic resonance
pyrazolines
Sodium acetate
Synthesis
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Summary:A series of pyrazolines were synthesized by Michael addition of chalcones with hydrazine hydrate in the presence of sodium acetate under conventional heating and microwave irradiation. The structures of the newly synthesized chalcones and pyrazolines were established based on IR, 1H- and 13C-NMR and mass spectral data. All the synthesized compounds were screened for their antimicrobial activity. Some of the compounds showed very good activity compared to standard drugs against all pathogenic bacteria and fungi.
ISSN:0352-5139
1820-7421
DOI:10.2298/JSC140021101A