Visualization of Chronic Myocardial Infarction Using the Intravascular Contrast Agent MS-325 (Gadofosveset) in Patients

Aims. The aim of this study was to evaluate the potential of visualizing chronic myocardial infarction in patients using the intravascular CA MS-325 (gadofosveset, EPIX Pharmaceuticals, Mass, USA). Methods. Nine patients were enrolled in a clinical phase II multicenter trial for MRCA and perfusion i...

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Bibliographic Details
Published in:TheScientificWorld 2012-01, Vol.2012 (2012), p.1-6
Main Authors: Schnackenburg, Bernhard, Fleck, Eckart, Thouet, Thomas, Kelle, Sebastian, Nagel, Eike, Kokocinski, Thomas
Format: Article
Language:English
Subjects:
Adult
Aged
Body weight
Cardiac patients
Chronic Disease
Clinical Study
Contrast agents
Contrast Media
Diagnosis
Female
Gadolinium
Gadolinium DTPA
Gadopentetate dimeglumine
Heart attack
Humans
Injection
Localization
Magnetic Resonance Angiography
Male
Medical imaging
Middle Aged
Myocardial infarction
Myocardial Infarction - diagnosis
Organometallic Compounds
Patients
Perfusion
Physiological aspects
Segments
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Summary:Aims. The aim of this study was to evaluate the potential of visualizing chronic myocardial infarction in patients using the intravascular CA MS-325 (gadofosveset, EPIX Pharmaceuticals, Mass, USA). Methods. Nine patients were enrolled in a clinical phase II multicenter trial for MRCA and perfusion imaging using MS-325. They had objective evidence of chronic myocardial infarction as visualized by previously performed late gadolinium (Gd) enhancement imaging (LGE) with a conventional extracellular Gd-DTPA CA (Magnevist, Bayer Healthcare, Germany, 0.2 mmol/kg/body weight) serving as reference standard. A prepulse-optimized LGE study was performed immediately and at several time points after injection of MS-325 (0.05 mmol/kg/body weight). The number and localization of segments demonstrating LGE with MS-325 as well as signal intensities were compared with the reference standard (Gd-DTPA). Results. Using MS-325, LGE could be detected at every time point in all 9 patients. The accuracy of LGE with MS-325 as compared to LGE with Gd-DTPA was highest 54±4 minutes after contrast injection, resulting in a sensitivity of 84% with a specificity of 98%. Conclusion. The intravascular CA MS-325 has the potential to visualize chronic myocardial infarction. However, in comparison with Gd-DTPA, the transmural extent and the number of segments are smaller.
ISSN:2356-6140
1537-744X
1537-744X
DOI:10.1100/2012/236401