Effects of restraint stress and nitric oxide synthase inhibition on learning and strategy preference in young adult male rats

The aim of this study was to investigate the effects of restraint stress and nitric oxide synthase (NOS) inhibition by NωNitro-L-Arginine (LNA) on learning and strategy preference. Rats were randomly divided into four groups (Saline, Saline+Stress, LNA, LNA+Stress). Stress was applied for one hour i...

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Bibliographic Details
Published in:Balkan medical journal 2012-12, Vol.29 (4), p.376-380
Main Authors: Dagdeviren, Melih, Dogan, Yusuf Hakan, Kanit, Lutfiye
Format: Article
Language:English
Subjects:
Learning
NOS inhibition
Original
restraint stress
strategy preference
water maze
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Summary:The aim of this study was to investigate the effects of restraint stress and nitric oxide synthase (NOS) inhibition by NωNitro-L-Arginine (LNA) on learning and strategy preference. Rats were randomly divided into four groups (Saline, Saline+Stress, LNA, LNA+Stress). Stress was applied for one hour in glass cylinders during 13 days. One hour after this stress application, water maze experiments were started. Injections (saline 1 ml/kg or 50 mg/kg LNA) were given 10 minutes before each experiment. The platform was kept visible or hidden (on the 4(th), 8(th), 12(th) days) at the same position. On the 13(th) day the platform was located on the opposite quadrant. Saline groups exhibited significantly better performances (F(1.31)=174.038 p
ISSN:2146-3123
2146-3131
DOI:10.5152/balkanmedj.2012.100