Lipid Profile in Adolescent Girls with Type 1 Diabetes Mellitus and Hyperandrogenemia

• Published in: International Journal of Endocrinology 2016-01, Vol.2016 (2016), p.392-399-145
• Main Authors: Klimek, Katarzyna, Drosdzol-Cop, Agnieszka, Gawlik, Aneta, Deja, Grazyna, Zachurzok, Agnieszka, Malecka-Tendera, Ewa
• Format: Article
• Language: English
• Subjects: Adrenal gland diseases; Age; Androgens; Antibodies; Atherosclerosis; Blood lipids; Cardiovascular disease; Cholesterol; Comparative analysis; Complications and side effects; Diabetes; Endocrinology; Enzymes; Genetic aspects; Girls; Immunoassay; Insulin resistance; Lipids; Menstruation; Physiological aspects; Polycystic ovary syndrome; Statistical analysis; Type 1 diabetes
• ISSN: 1687-8337; 1687-8345
• DOI: 10.1155/2016/9473158

Study Objectives. The study aim was to evaluate whether hyperandrogenemia in adolescent girls with type 1 diabetes mellitus (T1DM) may adversely influence lipid profile. Design and Participants. Lipid levels in 16 diabetic girls with biochemical hyperandrogenemia (T1DM-H) aged 16.3 ± 1.2 years were compared to 38 diabetic girls with normal androgen levels (T1DM-N) aged 15.8 ± 1.2 years. 15 healthy girls served as controls (CG). In all patients, anthropometric measurements were done, and androgens and SHBG were assessed. Results. In T1DM-H, total cholesterol (TC) and low density cholesterol (LDL-ch) were significantly higher than in CG (196.1 ± 41.2 versus 162.7 ± 31.7 mg/dL, p=0.01; 117.3 ± 33.1 versus 91.3 ± 27.8 mg/dL, p=0.01, resp.). Their LDL-ch, non-high density cholesterol (non-HDL-ch) concentrations, and LDL/HDL ratio were also significantly higher than in T1DM-N (117.3 ± 33.1 versus 97.7 ± 26.7 mg/dL, p=0.03; 137.3 ± 42.9 versus 113.3 ± 40.4 mg/dL, p=0.04; 2.8 ± 3.7 versus 1.6 ± 0.5, p=0.04, resp.). In stepwise multiple linear regression, free androgen index (FAI) and waist-to-hip ratio (WHR) were associated with TC (R2=0.4, p