A Concise Synthesis of Sacidumlignan B

A short synthesis of racemic Sacidumlignan B was achieved for the first time. The key steps included a formal reductive coupling between the diaryl ketone and the crotyl bromide, and the subsequent Friedel–Crafts cyclization, which led to an efficient construction of dihydronaphthalene skeleton in t...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-09, Vol.27 (18), p.5775
Main Authors: Zhuang, Zhiyuan, Luo, Zhenbiao, Yao, Sichen, Wang, Yawen, Peng, Yu
Format: Article
Language:English
Subjects:
Alcohol
Barbier reaction
Chemical properties
Chromatography
cyclization
cyclolignan
Ketones
Naphthalene
Natural products
Organic compounds
Oxidation-reduction reaction
Synthesis
synthetic efficiency
total synthesis
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Summary:A short synthesis of racemic Sacidumlignan B was achieved for the first time. The key steps included a formal reductive coupling between the diaryl ketone and the crotyl bromide, and the subsequent Friedel–Crafts cyclization, which led to an efficient construction of dihydronaphthalene skeleton in this 2,7′-cyclolignan natural product.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27185775