Molecular characterization of the severe falciparum malaria with typhoid co-infection: A case report

Malaria and typhoid co-infections can be a serious public health issue in tropical countries leading to incorrect diagnosis due to overlapping clinical presentations of malaria and typhoid and hence, causing a delay in implementing the appropriate treatment regimen for these concurrent infections. T...

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Bibliographic Details
Published in:Journal of vector borne diseases 2022-01, Vol.59 (1), p.105-107
Main Authors: Chaudhry, Shewta, Arya, Aditi, Matlani, Monika, Meena, Shyam, Pande, Veena, Singh, Vineeta
Format: Article
Language:English
Subjects:
Analysis
Blood
Case reports
coinfections
falciparum malaria
typhoid
drug resistance
hematological and molecular markers
Diagnosis
Ethylenediaminetetraacetic acid
Health aspects
Infection
Malaria
Medical examination
Medical research
Medicine, Experimental
Plasmodium falciparum
Typhoid fever
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Summary:Malaria and typhoid co-infections can be a serious public health issue in tropical countries leading to incorrect diagnosis due to overlapping clinical presentations of malaria and typhoid and hence, causing a delay in implementing the appropriate treatment regimen for these concurrent infections. This study reports a case of six-year-old female child co-infected with severe malaria (Plasmodium falciparum) and typhoid (Salmonella typhi) diagnosed by rapid malaria antigen test (RMAT) and blood culture respectively. Further, analysis of the chloroquine resistance gene Pfcrt for the falciparum demonstrated the presence of K76T mutant allele in pfcrt gene with high IC50 (150nM) for chloroquine (CQ) drug. The present case highlights the significance of timely identification and treatment of co-infections and also provides information about the circulating P. falciparum clinical strains.
ISSN:0972-9062
DOI:10.4103/0972-9062.331416