Venous gas caused by emphysematous pyelonephritis: a case report and review of literature

• Published in: BMC urology 2022-09, Vol.22 (1), p.1-154, Article 154
• Main Authors: Dong, Xue, You, Shuzong, Zhang, Huangqi, Wang, Dongnv, Pan, Wenting, Zhang, Binhao, Huang, Shanqiang, Li, Xin, Pang, Jianxin, Ji, Wenbin
• Format: Article
• Language: English
• Subjects: Abdomen; Abscesses; Antibiotics; Bacterial infections; Beta lactamases; Blood clot; Blood vessels; Bubbles; Case Report; Case reports; Computed tomography; Consciousness; CT imaging; Diabetes; Diabetes mellitus (non-insulin dependent); Diagnosis; E coli; Emphysematous pyelonephritis; Escherichia coli; Health aspects; Infection; Infections; Knowledge; Medical imaging; Parenchyma; Pathogenesis; Patients; Pyelonephritis; Sepsis; Thrombosis; Tomography; Treatment; Type 2 diabetes; Urology; Uterus; Veins; Veins & arteries; Venous gas; Vomiting; β Lactamase
• ISSN: 1471-2490; 1471-2490
• DOI: 10.1186/s12894-022-01104-6

Background Emphysematous pyelonephritis (EPN) is a potentially life-threatening disease caused by a gas-producing necrotizing bacterial infection that involves the renal parenchyma, collecting system, and/or perinephric tissue. EPN is often complicated by a previous diagnosis of diabetes mellitus, and venous air bubbles are an uncommon complication of it. We describe a 52-year-old woman who was admitted in coma, with a history of vomiting, and was found to have EPN with air bubbles in the uterine veins. We discuss the presentation, diagnosis, and pathogenesis of this uncommon but clinically significant event, and briefly review other case reports of venous gas or thrombosis caused by EPN. Case presentation We report the case of a 52-year-old woman with past history of type 2 diabetes mellitus, presenting with loss of consciousness after vomiting for half a day. Abdominal computed tomography scan revealed unilateral EPN with air bubbles in the uterine veins. The blood, pus, and urine cultures were positive for extended-spectrum beta-lactamase-producing Escherichia coli. The patient's condition improved well after conservative management comprising supportive measures, broad-spectrum antibiotics, percutaneous drainage therapy, and an open operation. Conclusions Venous air bubbles are rare but fatal complication of EPN. Early diagnosis and treatment are critical to ensure good results. Keywords: Emphysematous pyelonephritis, Venous gas, Escherichia coli, Treatment, Pathogenesis