Portable Iontophoresis Device for Efficient Drug Delivery

The timely delivery of drugs to specific locations in the body is imperative to ensure the efficacy of treatment. This study introduces a portable facial device that can deliver drugs efficiently using iontophoresis. Two types of power supplies-direct current and pulse ionization supplies-were manuf...

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Bibliographic Details
Published in:Bioengineering (Basel) 2023-01, Vol.10 (1), p.88
Main Authors: Bok, Moonjeong, Kwon, Young Il, Huang, Zheng Min, Lim, Eunju
Format: Article
Language:English
Subjects:
Absorption
Bioengineering
Cadavers
diffusion
Direct current
drug absorption
Drug delivery
Drug delivery systems
Drug development
Drugs
Electric currents
Electric fields
Electrical stimuli
Electricity
Electrodes
Injection molding
Ionization
Iontophoresis
Medical equipment
Moisture content
Moisture effects
Molecular weight
Portable equipment
Power supply
Rhodamine
Silver
Simulation
Skin
Software
transdermal administration
Transdermal medication
Water content
Wearable technology
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Summary:The timely delivery of drugs to specific locations in the body is imperative to ensure the efficacy of treatment. This study introduces a portable facial device that can deliver drugs efficiently using iontophoresis. Two types of power supplies-direct current and pulse ionization supplies-were manufactured by injection molding. Electrical stimulation elements, which contained Ag metal wires, were woven into facial mask packs. The diffusion phenomenon in the skin and iontophoresis were numerically modeled. Injection molding was simulated before the device was manufactured. Analysis using rhodamine B demonstrated a remarkable increase in the moisture content of the skin and effective absorption of the drug under an applied electric field upon the application of iontophoresis. The proposed concept and design constitute a new method of achieving effective drug absorption with wearable devices.
ISSN:2306-5354
2306-5354
DOI:10.3390/bioengineering10010088