Comparison of cognitive performance between patients with Parkinson’s disease and dystonia using an intraoperative recognition memory test

• Published in: Scientific reports 2021-10, Vol.11 (1), p.20724-20724, Article 20724
• Main Authors: Shi, Lin, Yuan, Tianshuo, Fan, Shiying, Diao, Yu, Qin, Guofan, Liu, Defeng, Zhu, Guanyu, Qin, Kai, Liu, Huanguang, Zhang, Hua, Yang, Anchao, Meng, Fangang, Zhang, Jianguo
• Format: Article
• Language: English
• Subjects: 631/378/1595; 692/617/375/346/1718; Basal ganglia; Cognition - physiology; Cognitive ability; Deep brain stimulation; Dystonia; Dystonia - physiopathology; Female; Humanities and Social Sciences; Humans; Male; Memory; Memory - physiology; Mental Status and Dementia Tests; Middle Aged; Movement disorders; multidisciplinary; Neurodegenerative diseases; Neuropsychological Tests; Parkinson Disease - physiopathology; Parkinson's disease; Patients; Science; Science (multidisciplinary); Surgery
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-99317-6

Neuroscientific studies on the function of the basal ganglia often examine the behavioral performance of patients with movement disorders, such as Parkinson’s disease (PD) and dystonia (DT), while simultaneously examining the underlying electrophysiological activity during deep brain stimulation surgery. Nevertheless, to date, there have been no studies comparing the cognitive performance of PD and DT patients during surgery. In this study, we assessed the memory function of PD and DT patients with the Montreal Cognitive Assessment (MoCA) and the Mini-Mental State Examination (MMSE). We also tested their cognitive performance during the surgery using a continuous recognition memory test. The results of the MoCA and MMSE failed to reveal significant differences between the PD and DT patients. Additionally, no significant difference was detected by the intraoperative memory test between the PD and DT patients. The intraoperative memory test scores were highly correlated with the MMSE scores and MoCA scores. Our data suggest that DT patients perform similarly to PD patients in cognitive tests during surgery, and intraoperative memory tests can be used as a quick memory assessment tool during surgery.