Application of stem cells in the repair of intervertebral disc degeneration

Intervertebral disc degeneration (IDD) is a common disease that increases with age, and its occurrence is stressful both psychologically and financially. Stem cell therapy for IDD is emerging. For this therapy, stem cells from different sources have been proven in vitro, in vivo, and in clinical tri...

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Bibliographic Details
Published in:Stem cell research & therapy 2022-02, Vol.13 (1), p.70-70, Article 70
Main Authors: Zhang, Wentao, Sun, Tianze, Li, Ying, Yang, Ming, Zhao, Yantao, Liu, Jing, Li, Zhonghai
Format: Article
Language:English
Subjects:
Aging
Back pain
Bone marrow
Cell therapy
Chemokines
Clinical trials
Cytokines
Degeneration
Degenerative disc disease
Growth factors
Humans
Intervertebral Disc
Intervertebral disc degeneration
Intervertebral Disc Degeneration - therapy
Intervertebral discs
Kinases
Mechanical properties
Quality of life
Repair
Reverse degeneration
Review
Senescence
Stem cell
Stem cell research
Stem Cells
Therapy
Transplantation
Tumor necrosis factor-TNF
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Summary:Intervertebral disc degeneration (IDD) is a common disease that increases with age, and its occurrence is stressful both psychologically and financially. Stem cell therapy for IDD is emerging. For this therapy, stem cells from different sources have been proven in vitro, in vivo, and in clinical trials to relieve pain and symptoms, reverse the degeneration cascade, delay the aging process, maintain the spine shape, and retain mechanical function. However, further research is needed to explain how stem cells play these roles and what effects they produce in IDD treatment. This review aims to summarize and objectively analyse the current evidence on stem cell therapy for IDD.
ISSN:1757-6512
1757-6512
DOI:10.1186/s13287-022-02745-y